[Term]
id: PR:000000415
name: activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form
def: "An activin receptor type-2B isoform ActR-IIB2 that includes at least one glycosylated residue and at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "ACVR2B/iso:1/GlycoPhos+" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB2/GlycoPhos+" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1 glycosylated and phosphorylated form" EXACT [PRO:CNA]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000209 ! activin receptor type-2B isoform ActR-IIB2

[Term]
id: PR:Q90670-1
name: activin receptor type-2B isoform ActR-IIB2 (chicken)
def: "An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of chicken." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "chick-ACVR2B/iso:ActR-IIB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q90670-1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000209 ! activin receptor type-2B isoform ActR-IIB2

[Term]
id: PR:000046259
name: activin receptor type-2B, signal peptide removed form (human)
def: "An activin receptor type-2B (human) that has had the signal peptide removed. UniProtKB:Q13705, 19-512." [PRO:DNx, Reactome:R-HSA-201656]
comment: Category=organism-modification.
synonym: "PRO_0000024404" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hACVR2B/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705, 19-512" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201656 "PR:000046259 located_in GO:0005886"
intersection_of: PR:Q13705 ! activin receptor type-2B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000209
name: activin receptor type-2B isoform ActR-IIB2
def: "An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform lacks the intracellular segment rich in basic and acidic residues (known as splicing cassette II).
synonym: "ACVR2B isoform 1" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB2" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000071 ! activin receptor type-2B

[Term]
id: PR:000000215
name: activin receptor type-2B sequence variant V494I (human)
def: "An activin receptor type-2B (human) that has an Ile residue at the position equivalent to Val-494 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009." [PMID:9916847, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hACVR2B/var:V494I" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705-1, Val-494, CHEBI:30009" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "activin receptor type-2B sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013282
is_a: PR:Q13705 ! activin receptor type-2B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000214
name: activin receptor type-2B sequence variant R40H (human)
def: "An activin receptor type-2B (human) that has a His residue at the position equivalent to Arg-40 of the amino acid sequence represented by UniProtKB:Q13705-1. This variation is within the extracellular domain. Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979." [PMID:9916847, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hACVR2B/var:R40H" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705-1, Arg-40, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "activin receptor type-2B sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013281
is_a: PR:Q13705 ! activin receptor type-2B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27040-4
name: activin receptor type-2B isoform ActR-IIB4 (mouse)
def: "An activin receptor type-2B isoform ActR-IIB4 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mACVR2B/iso:ActR-IIB4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27040-4
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000213 ! activin receptor type-2B isoform ActR-IIB4

[Term]
id: PR:000000211
name: activin receptor type-2B isoform ActR-IIB1
def: "An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-1 or a 1:1 ortholog thereof." [PMID:1310075, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "ACVR2B isoform 3" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 3" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000071 ! activin receptor type-2B

[Term]
id: PR:000000210
name: activin receptor type-2B isoform ActR-IIBtrunc
def: "An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13705-2 or a 1:1 ortholog thereof." [PMID:9916847, PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This form may have dominant-negative properties.
synonym: "ActR-IIB1" RELATED []
synonym: "ACVR2B isoform 2" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIBtrunc" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 2" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000071 ! activin receptor type-2B

[Term]
id: PR:000000213
name: activin receptor type-2B isoform ActR-IIB4
def: "An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform lacks the cluster of proline residues within the extracellular domain located immediately before the transmembrane region (known as splicing cassette I) and lacks the intracellular segment rich in basic and acidic residues (known as splicing cassette II).
synonym: "ACVR2B isoform 5" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB4" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 5" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000071 ! activin receptor type-2B

[Term]
id: PR:000000212
name: activin receptor type-2B isoform ActR-IIB3
def: "An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform lacks the cluster of proline residues within the extracellular domain located immediately before the transmembrane region (known as splicing cassette I).
synonym: "ACVR2B isoform 4" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB3" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 4" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000071 ! activin receptor type-2B

[Term]
id: PR:Q13705-1
name: activin receptor type-2B isoform ActR-IIB2 (human)
def: "An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACVR2B/iso:ActR-IIB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13705-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000209 ! activin receptor type-2B isoform ActR-IIB2

[Term]
id: PR:Q13705-2
name: activin receptor type-2B isoform ActR-IIBtrunc (human)
def: "An activin receptor type-2B isoform ActR-IIBtrunc that is encoded in the genome of human." [PMID:9916847, PRO:DNx, UniProtKB:Q13705]
comment: Category=organism-sequence.
synonym: "hACVR2B/iso:ActR-IIB1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform ActR-IIB1 (human)" EXACT [UniProtKB:Q13705]
xref: UniProtKB:Q13705-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000210 ! activin receptor type-2B isoform ActR-IIBtrunc

[Term]
id: PR:P27040-1
name: activin receptor type-2B isoform ActR-IIB1 (mouse)
def: "An activin receptor type-2B isoform ActR-IIB1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mACVR2B/iso:ActR-IIB1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27040-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000211 ! activin receptor type-2B isoform ActR-IIB1

[Term]
id: PR:000000529
name: activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
def: "An activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form in which the phosphorylation occurs at Ser/Thr residues within the GS-motif, and constitutes an active activin receptor subunit." [PRO:CNA]
comment: Category=modification.
synonym: "ACVR2B/iso:1/GlycoPhos:1" EXACT [PRO:DNx]
synonym: "ACVR2B/iso:ActR-IIB2/NGlycoPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1 glycosylated and phosphorylated 1" EXACT [PRO:CNA]
is_a: PR:000000415 ! activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form
relationship: has_part MOD:00006 ! N-glycosylated residue
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q90670
name: activin receptor type-2B (chicken)
def: "An activin receptor type-2B that is encoded in the genome of chicken." [OMA:Q90670, PRO:DNx]
comment: Category=organism-gene.
synonym: "ACVR2B" RELATED Gene-based [UniProtKB:Q90670]
synonym: "chick-ACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB (chicken)" EXACT [UniProtKB:Q90670]
synonym: "activin receptor type IIB (chicken)" EXACT [UniProtKB:Q90670]
xref: UniProtKB:Q90670
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000071 ! activin receptor type-2B
relationship: has_gene_template NCBIGene:374213 ! ACVR2B (chicken)

[Term]
id: PR:Q13705
name: activin receptor type-2B (human)
def: "An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705]
comment: Category=organism-gene.
synonym: "ACVR2B" RELATED Gene-based [UniProtKB:Q13705]
synonym: "hACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB (human)" EXACT [UniProtKB:Q13705]
synonym: "activin receptor type IIB (human)" EXACT [UniProtKB:Q13705]
xref: DTO:03100039
xref: UniProtKB:Q13705
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000071 ! activin receptor type-2B
relationship: has_gene_template HGNC:174 ! ACVR2B (human)

[Term]
id: PR:P27040
name: activin receptor type-2B (mouse)
def: "An activin receptor type-2B that is encoded in the genome of mouse." [OMA:P27040, PRO:DNx]
comment: Category=organism-gene.
synonym: "Acvr2b" RELATED Gene-based [UniProtKB:P27040]
synonym: "mACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB (mouse)" EXACT [UniProtKB:P27040]
synonym: "activin receptor type IIB (mouse)" EXACT [UniProtKB:P27040]
xref: UniProtKB:P27040
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000071 ! activin receptor type-2B
relationship: has_gene_template MGI:87912 ! Acvr2b (mouse)

[Term]
id: PR:000000071
name: activin receptor type-2B
def: "A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB" EXACT []
synonym: "activin receptor type IIB" EXACT []
xref: IUPHARobj:1792
xref: PIRSF:PIRSF500456
is_a: PR:000000007 ! TGF-beta superfamily receptor type-2 with activin receptor domain

[Term]
id: PR:P38445
name: activin receptor type-2B (rat)
def: "An activin receptor type-2B that is encoded in the genome of rat." [OMA:P38445, PRO:DNx]
comment: Category=organism-gene.
synonym: "Acvr2b" RELATED Gene-based [UniProtKB:P38445]
synonym: "Actriib" RELATED Gene-based [UniProtKB:P38445]
synonym: "rACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB (rat)" EXACT [UniProtKB:P38445]
synonym: "activin receptor type IIB (rat)" EXACT [UniProtKB:P38445]
xref: UniProtKB:P38445
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000071 ! activin receptor type-2B
relationship: has_gene_template RGD:2028 ! Acvr2b (rat)

[Term]
id: PR:P27040-3
name: activin receptor type-2B isoform ActR-IIB3 (mouse)
def: "An activin receptor type-2B isoform ActR-IIB3 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mACVR2B/iso:ActR-IIB3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27040-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000212 ! activin receptor type-2B isoform ActR-IIB3

[Term]
id: PR:P27040-2
name: activin receptor type-2B isoform ActR-IIB2 (mouse)
def: "An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mACVR2B/iso:ActR-IIB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27040-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000209 ! activin receptor type-2B isoform ActR-IIB2

[Term]
id: PR:000036443
name: activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
def: "An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "hACVR2B/iso:1/GlycoPhos:1" EXACT [PRO:DNx]
synonym: "hACVR2B/iso:ActR-IIB2/NGlycoPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1 glycosylated and phosphorylated 1 (human)" EXACT [PRO:CNA]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000529 ! activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
relationship: has_part MOD:00006 ! N-glycosylated residue
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000036442
name: activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
def: "An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:1326537, PMID:16991118, PMID:8721982, PRO:CNA]
comment: Category=organism-modification.
synonym: "mACVR2B/iso:1/GlycoPhos:1" EXACT [PRO:DNx]
synonym: "mACVR2B/iso:ActR-IIB2/NGlycoPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1 glycosylated and phosphorylated 1 (mouse)" EXACT [PRO:CNA]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000529 ! activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
relationship: has_part MOD:00006 ! N-glycosylated residue
relationship: has_part MOD:00696 ! phosphorylated residue