Protein Ontology Report - hTBK1 PR:Q9UHD2 - http://purl.obolibrary.org/obo/PR_Q9UHD2

This page represents a class of proteins encompassing all the protein products of the TBK1 gene in human .

Ontology Information
PRO ID	PR:Q9UHD2 Show OBO stanza / PAF
PRO name	serine/threonine-protein kinase TBK1 (human)
Synonyms	PRO-short-label: hTBK1 EXACT: NF-kappa-B-activating kinase (human); T2K (human); TANK-binding kinase 1 (human) Gene-based: NAK; TBK1
Definition	A serine/threonine-protein kinase TBK1 that is encoded in the genome of human. [PMID:17327220, PRO:CNA, Reactome:R-HSA-166267]
PRO Category	organism-gene
Parent	PR:000001779 serine/threonine-protein kinase TBK1
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100518, HGNC:11584, Reactome:R-HSA-166267, UniProtKB:Q9UHD2

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTBK1 forms found in complexes

hTBK1 Component Complexes PR:000028695 hTBK1/Phos:1 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028695 hTBK1/Phos:1 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028695 hTBK1/Phos:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000028695 hTBK1/Phos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000028695 hTBK1/Phos:1 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028695 hTBK1/Phos:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26959 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_6809 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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