Protein Ontology Report - mTIRAP PR:Q99JY1 - http://purl.obolibrary.org/obo/PR_Q99JY1

This page represents a class of proteins encompassing all the protein products of the TIRAP gene in mouse .

Ontology Information
PRO ID	PR:Q99JY1 Show OBO stanza / PAF
PRO name	Toll/interleukin-1 receptor domain-containing adapter protein (mouse)
Synonyms	PRO-short-label: mTIRAP EXACT: MyD88 adapter-like protein (mouse); TIR domain-containing adapter protein (mouse); adaptor protein Wyatt (mouse) Gene-based: Mal; Tirap
Definition	A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
PRO Category	organism-gene
Parent	PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 0 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	MGI:2152213, UniProtKB:Q99JY1

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

mTIRAP forms found in complexes

mTIRAP Component Complexes PR:000001751 TIRAP PR:000036006 TIRAP:PIP2 complex PR:000001751 TIRAP PR:000025784 MYD88:TIRAP:activated TLR4 receptor PR:000001751 TIRAP PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000027216 mTIRAP/Phos:1 PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:000027216 mTIRAP/Phos:1 PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse) PR:Q99JY1 mTIRAP PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse) PR:Q99JY1 mTIRAP PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse) PR:Q99JY1 mTIRAP PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse) PR:Q99JY1 mTIRAP PR:000036007 TIRAP:PIP2 complex (mouse) PR:Q99JY1 mTIRAP PR:000027196 TIRAP:PIP2:activated TLR4 (mouse) PR:Q99JY1 mTIRAP PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:Q99JY1 mTIRAP PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:Q99JY1 mTIRAP PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:Q99JY1 mTIRAP PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:Q99JY1 mTIRAP PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000001751 TIRAP has_part Pfam:PF01582 TIR domain PR:000027196 TIRAP:PIP2:activated TLR4 (mouse) participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442 PR:000036007 TIRAP:PIP2 complex (mouse) participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway PMID:11544529 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse) participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665 Biological Process GO Term Protein Forms & Complexes Evidence GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse) PMID:12538665 GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027196 TIRAP:PIP2:activated TLR4 (mouse) PMID:12447442 GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036007 TIRAP:PIP2 complex (mouse) PMID:11544529

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