Protein Ontology Report - hSARM1 PR:Q6SZW1 - http://purl.obolibrary.org/obo/PR_Q6SZW1

This page represents a class of proteins encompassing all the protein products of the SARM1 gene in human .

Ontology Information
PRO ID	PR:Q6SZW1 Show OBO stanza / PAF
PRO name	NAD(+) hydrolase SARM1 (human)
Synonyms	PRO-short-label: hSARM1 EXACT: HsTIR; MyD88-5 (human); NADP(+) hydrolase SARM1 (human); NADase SARM1 (human); SAM domain-containing protein 2 (human); Tir-1 homolog (human); sterile alpha and Armadillo repeat protein (human); sterile alpha and TIR motif-containing protein 1 (human); sterile alpha motif domain-containing protein 2 (human) Gene-based: KIAA0524; SAMD2; SARM; SARM1
Definition	An NAD(+) hydrolase SARM1 that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000014458 NAD(+) hydrolase SARM1
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:17074, UniProtKB:Q6SZW1

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSARM1 forms found in complexes
hSARM1 Component Complexes PR:Q6SZW1-1 hSARM1/iso:1 PR:000037330 SARM:ticam1:activated TLR3 complex (human) PR:Q6SZW1-1 hSARM1/iso:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_151758 participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758 PR:000037330 SARM:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 Biological Process GO Term Protein Forms & Complexes Evidence GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151758 PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151758 PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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