Protein Ontology Report - hCASP8 PR:Q14790 - http://purl.obolibrary.org/obo/PR_Q14790

This page represents a class of proteins encompassing all the protein products of the CASP8 gene in human .

Ontology Information
PRO ID	PR:Q14790 Show OBO stanza / PAF
PRO name	caspase-8 (human)
Synonyms	PRO-short-label: hCASP8 EXACT: CAP4 (human); CASP-8 (human); FADD-homologous ICE/ced-3-like protease (human); FADD-like ICE (human); FLICE (human); ICE-like apoptotic protease 5 (human); MACH (human); MORT1-associated ced-3 homolog (human); apoptotic cysteine protease (human); apoptotic protease Mch-5 (human) Gene-based: CASP8; MCH5
Definition	A caspase-8 that is encoded in the genome of human. [PRO:DNx]
PRO Category	organism-gene
Parent	PR:000002317 caspase-8
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 9 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:1509, Reactome:R-HSA-57031, UniProtKB:Q14790

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hCASP8 forms found in complexes

hCASP8 Component Complexes PR:000036063 hCASP8/iso:1/Clv:1 PR:000036068 caspase-8 complex (human) PR:000036065 hCASP8/iso:1/Clv:2 PR:000036068 caspase-8 complex (human) PR:Q14790 hCASP8 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human) PR:Q14790 hCASP8 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) PR:Q14790 hCASP8 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344 located_in GO:0010008 endosome membrane Reactome:REACT_151344 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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