Protein Ontology Report - hRIPK1 PR:Q13546 - http://purl.obolibrary.org/obo/PR_Q13546

This page represents a class of proteins encompassing all the protein products of the RIPK1 gene in human .

Ontology Information
PRO ID	PR:Q13546 Show OBO stanza / PAF
PRO name	receptor-interacting serine/threonine-protein kinase 1 (human)
Synonyms	PRO-short-label: hRIPK1 EXACT: RIP-1 (human); cell death protein RIP (human); receptor-interacting protein 1 (human) Gene-based: RIP; RIP1; RIPK1
Definition	A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx]
PRO Category	organism-gene
Parent	PR:000014022 receptor-interacting serine/threonine-protein kinase 1
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100450, HGNC:10019, Reactome:R-HSA-168651, Reactome:R-HSA-450326, UniProtKB:Q13546

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hRIPK1 forms found in complexes

hRIPK1 Component Complexes PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) PR:Q13546 hRIPK1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) PR:Q13546 hRIPK1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) PR:Q13546 hRIPK1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) PR:Q13546 hRIPK1 PR:000028437 TRAF2:TRADD:RIP1:FADD (human) PR:Q13546 hRIPK1 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human) PR:Q13546 hRIPK1 PR:000028434 TRAF2:TRADD:RIP1 complex (human) PR:Q13546 hRIPK1 PR:000037334 rip1:ticam1:activated TLR3 complex (human) PR:Q13546 hRIPK1 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human) PR:Q13546 hRIPK1 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) PR:Q13546 hRIPK1 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26016 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036051 hRIPK1/K63polyUbiq:1 Lys-377, PR:000044772 located_in GO:0005737 cytoplasm Reactome:REACT_26236 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25755 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344 located_in GO:0010008 endosome membrane Reactome:REACT_151344 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_151344 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25948 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036649 hRIPK1/iso:1/Ubiq:1 capable_of GO:0005515 protein binding with PR:Q8C669 mPELI1 PMID:19734906 PR:000037334 rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005737 cytoplasm PR:000036051 hRIPK1/K63polyUbiq:1 Lys-377, PR:000044772 Reactome:REACT_26236 GO:0010008 endosome membrane PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25755 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26016 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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