Protein Ontology Report - hMAD2L1 PR:Q13257 - http://purl.obolibrary.org/obo/PR_Q13257

This page represents a class of proteins encompassing all the protein products of the MAD2L1 gene in human .

Ontology Information
PRO ID	PR:Q13257 Show OBO stanza / PAF
PRO name	mitotic spindle assembly checkpoint protein MAD2A (human)
Synonyms	PRO-short-label: hMAD2L1 EXACT: HsMAD2; MAD2-like protein 1 (human); mitotic arrest deficient 2-like protein 1 (human) Gene-based: MAD2; MAD2L1
Definition	A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human. [PMID:12719470, PMID:15525512, PMID:15592459, PMID:20624902, PRO:KER]
PRO Category	organism-gene
Parent	PR:000010038 mitotic spindle assembly checkpoint protein MAD2A
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:6763, UniProtKB:Q13257

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification

PRO ID & Category Annotation Complex Name Short Label Definition & Comment PR:Q13257   1 10 organism-gene mitotic spindle assembly checkpoint protein MAD2A (human) hMAD2L1 A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human. PR:Q13257-2     organism-sequence mitotic spindle assembly checkpoint protein MAD2A isoform h2 (human) hMAD2L1/iso:h2 A mitotic spindle assembly checkpoint protein MAD2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13257-2. PR:000042259   1  organism-modification mitotic spindle assembly checkpoint protein MAD2A, initiator methionine removed form (human) hMAD2L1/InitMet- A mitotic spindle assembly checkpoint protein MAD2A (human) that has had the initiator methionine removed. Example: UniProtKB:Q13257-1, 2-205. PR:Q13257-1     organism-sequence mitotic spindle assembly checkpoint protein MAD2A isoform 1 (human) hMAD2L1/iso:1 A mitotic spindle assembly checkpoint protein MAD2A isoform 1 that is encoded in the genome of human.

hMAD2L1 forms found in complexes
hMAD2L1 Component Complexes PR:000042259 hMAD2L1/InitMet- PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human) PR:Q13257 hMAD2L1 PR:000035568 MAD1:MAD2 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:Q13257 hMAD2L1 capable_of GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 BioGRID:BG-718929, MINT:MINT-8289277 capable_of GO:0005515 protein binding with PR:O43684 hBUB3 BioGRID:BG-718926 capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302957 capable_of GO:0031625 ubiquitin protein ligase binding PMID:20624902 capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512 capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:20624902 capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:20624902 located_in GO:0000776 kinetochore PMID:12719470 participates_in NOT GO:0051310 metaphase plate congression PMID:15592459 participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512 Biological Process GO Term Protein Forms & Complexes Evidence NOT GO:0051310 metaphase plate congression PR:Q13257 hMAD2L1 PMID:15592459 GO:0051444 negative regulation of ubiquitin-protein transferase activity PR:Q13257 hMAD2L1 PMID:15525512 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:Q13257 hMAD2L1 PMID:12719470

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