Protein Ontology Report - hTTK PR:P33981 - http://purl.obolibrary.org/obo/PR_P33981

This page represents a class of proteins encompassing all the protein products of the TTK gene in human .

Ontology Information
PRO ID	PR:P33981 Show OBO stanza / PAF
PRO name	dual specificity protein kinase TTK (human)
Synonyms	PRO-short-label: hTTK EXACT: PYT (human); phosphotyrosine picked threonine-protein kinase (human) Gene-based: MPS1; MPS1L1; TTK
Definition	A dual specificity protein kinase TTK that is encoded in the genome of human. [PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000016787 dual specificity protein kinase TTK
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100547, HGNC:12401, UniProtKB:P33981

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:P33981 hTTK capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-590746 located_in GO:0000776 kinetochore PMID:20624902 participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840 participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0034501 protein localization to kinetochore PMID:22732840 participates_in GO:0034501 protein localization to kinetochore PMID:20624902 participates_in GO:0051310 metaphase plate congression PMID:20624902, PMID:22732840 participates_in GO:0032092 positive regulation of protein binding PMID:22660415 participates_in GO:0032092 positive regulation of protein binding PMID:20624902 participates_in GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902 participates_in GO:0031577 spindle checkpoint signaling PMID:20624902 PR:000045754 hTTK/Phos:1 Thr-676, MOD:00047 capable_of GO:0004672 protein kinase activity PMID:18680479 participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698 participates_in GO:0051298 centrosome duplication PMID:17728254 participates_in GO:0071174 mitotic spindle checkpoint signaling PMID:18083840 PR:000049845 hTTK/p(Act-loop_P+1-loop) capable_of GO:0004672 protein kinase activity PMID:19120698 PR:000049844 hTTK/pActloop capable_of GO:0004672 protein kinase activity PMID:18680479, PMID:19120698 participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698 Biological Process GO Term Protein Forms & Complexes Evidence GO:0045841 negative regulation of mitotic metaphase/anaphase transition PR:P33981 hTTK PMID:20624902 GO:0051298 centrosome duplication PR:000045754 hTTK/Phos:1 Thr-676, MOD:00047 PMID:17728254 GO:0071174 mitotic spindle checkpoint signaling PR:000045754 hTTK/Phos:1 Thr-676, MOD:00047 PMID:18083840 NOT GO:0034501 protein localization to kinetochore PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902 GO:0032092 positive regulation of protein binding PR:P33981 hTTK PMID:22660415 PR:P33981 hTTK PMID:20624902 GO:0046777 protein autophosphorylation PR:000045754 hTTK/Phos:1 Thr-676, MOD:00047 PMID:18680479, PMID:19120698 PR:000049844 hTTK/pActloop PMID:18680479, PMID:19120698 GO:0034501 protein localization to kinetochore PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902, PMID:22732840 PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902 PR:P33981 hTTK PMID:20624902, PMID:22732840 PR:P33981 hTTK PMID:22732840 PR:P33981 hTTK PMID:20624902 GO:0031577 spindle checkpoint signaling PR:P33981 hTTK PMID:20624902 GO:0051310 metaphase plate congression PR:P33981 hTTK PMID:20624902, PMID:22732840 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:P33981 hTTK PMID:20624902

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