Protein Ontology Report - hAPC PR:P25054 - http://purl.obolibrary.org/obo/PR_P25054

This page represents a class of proteins encompassing all the protein products of the APC gene in human .

Ontology Information
PRO ID	PR:P25054 Show OBO stanza / PAF
PRO name	adenomatous polyposis coli protein (human)
Synonyms	PRO-short-label: hAPC EXACT: deleted in polyposis 2.5 (human); protein APC (human) Gene-based: APC; DP2.5
Definition	An adenomatous polyposis coli protein that is encoded in the genome of human. [PMID:11283619, PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000004122 adenomatous polyposis coli protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 7
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:583, Reactome:R-HSA-2976015, Reactome:R-HSA-3361755, UniProtKB:P25054

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification

PRO ID & Category Annotation Complex Name Short Label Definition & Comment PR:P25054   1 8 organism-gene adenomatous polyposis coli protein (human) hAPC An adenomatous polyposis coli protein that is encoded in the genome of human. PR:P25054-1     organism-sequence adenomatous polyposis coli protein isoform h1A (human) hAPC/iso:h1A An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-1. PR:P25054-2     organism-sequence adenomatous polyposis coli protein isoform h2 (human) hAPC/iso:h2 An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-2. PR:P25054-3     organism-sequence adenomatous polyposis coli protein isoform h1B (human) hAPC/iso:h1B An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-3. PR:000046350     organism-modification adenomatous polyposis coli protein phosphorylated and ubiquitinated form (human) hAPC/PhosUbiq+ An adenomatous polyposis coli protein (human) that includes at least one phosphorylated residue and at least one ubiquitinated lysine. UniProtKB:P25054, MOD:00696|MOD:01148. PR:000046351     organism-modification adenomatous polyposis coli protein ubiquitinated form (human) hAPC/UbiqLys+ An adenomatous polyposis coli protein (human) that includes at least one ubiquitinated lysine. UniProtKB:P25054, MOD:01148. PR:000056237     organism-modification adenomatous polyposis coli protein N-glycosylated 1 (human) hAPC/NGlyco:1 An adenomatous polyposis coli protein (human) that has been N-glycosylated at the residue equivalent to Asn-1818 of the amino acid sequence represented by UniProtKB:P25054-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25054-1, Asn-1818, MOD:00160~GNO:G60923RB. Requested by=GlyGen PR:000030183     organism-modification adenomatous polyposis coli protein phosphorylated 1 (human) hAPC/Phos:1 An adenomatous polyposis coli protein phosphorylated 1 in human. Kinase=("BUB1:BUB3 complex"; PR:000035564).Note: In vitro PR:000030185     organism-modification adenomatous polyposis coli protein phosphorylated 2 (human) hAPC/Phos:2 An adenomatous polyposis coli protein phosphorylated 2 in human. Kinase=("Bub1b-Bub3 complex"; PR:000035563).Note: In vitro PR:000030187     organism-modification adenomatous polyposis coli protein phosphorylated 3 (human) hAPC/Phos:3 An adenomatous polyposis coli protein phosphorylated 3 in human. Kinase=("GSK3B"; PR:000008288).Note: In vitro PR:000030189     organism-modification adenomatous polyposis coli protein phosphorylated 4 (human) hAPC/Phos:4 An adenomatous polyposis coli protein phosphorylated 4 in human. Kinase=("Bub1"; PR:000004854). Kinase=("GSK3B"; PR:000008288).Note: In vitro

hAPC forms found in complexes
hAPC Component Complexes PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:P25054 hAPC capable_of GO:0008017 microtubule binding PMID:11283619 capable_of GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832 capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619 capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619 capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957 located_in GO:0000776 kinetochore PMID:11283619 participates_in GO:0007059 chromosome segregation PMID:11283619 participates_in NOT GO:0031577 spindle checkpoint signaling PMID:11283619 Biological Process GO Term Protein Forms & Complexes Evidence GO:0007059 chromosome segregation PR:P25054 hAPC PMID:11283619 NOT GO:0031577 spindle checkpoint signaling PR:P25054 hAPC PMID:11283619 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:P25054 hAPC PMID:11283619

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