Protein Ontology Report - hAPC PR:P25054 - http://purl.obolibrary.org/obo/PR_P25054

This page represents a class of proteins encompassing all the protein products of the APC gene in human .

Ontology Information
PRO ID	PR:P25054 Show OBO stanza / PAF
PRO name	adenomatous polyposis coli protein (human)
Synonyms	PRO-short-label: hAPC EXACT: deleted in polyposis 2.5 (human); protein APC (human) Gene-based: APC; DP2.5
Definition	An adenomatous polyposis coli protein that is encoded in the genome of human. [PMID:11283619, PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000004122 adenomatous polyposis coli protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 7
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:583, Reactome:R-HSA-2976015, Reactome:R-HSA-3361755, UniProtKB:P25054

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hAPC forms found in complexes
hAPC Component Complexes PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:P25054 hAPC capable_of GO:0008017 microtubule binding PMID:11283619 capable_of GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832 capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619 capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619 capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957 located_in GO:0000776 kinetochore PMID:11283619 participates_in GO:0007059 chromosome segregation PMID:11283619 participates_in NOT GO:0031577 spindle checkpoint signaling PMID:11283619 Biological Process GO Term Protein Forms & Complexes Evidence GO:0007059 chromosome segregation PR:P25054 hAPC PMID:11283619 NOT GO:0031577 spindle checkpoint signaling PR:P25054 hAPC PMID:11283619 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:P25054 hAPC PMID:11283619

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