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Protein Ontology Report - mMYD88

PR:P22366 - http://purl.obolibrary.org/obo/PR_P22366
This page represents a class of proteins encompassing all the protein products of the MYD88 gene in mouse .
Ontology Information
PRO ID PR:P22366 Show OBO stanza / PAF
PRO name myeloid differentiation primary response protein MyD88 (mouse)
Alternate ID PR:000025771
Synonyms
PRO-short-label: mMYD88
Definition A myeloid differentiation primary response protein MyD88 that is encoded in the genome of mouse. [OMA:P22366, PRO:CNA]
PRO Category organism-gene
Parent PR:000001740 myeloid differentiation primary response protein MyD88
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

mMYD88 forms found in complexes
mMYD88 Component Complexes
PR:000001740 MYD88 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:P22366-1 mMYD88/iso:1 PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-2 mMYD88/iso:2 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001740
MYD88
has_part Pfam:PF01582 TIR domain
has_part Pfam:PF00531 Death domain
PR:P22366-2
mMYD88/iso:2
participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)

PMID:12538665
PR:P22366-2 mMYD88/iso:2

PMID:12538665

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