Protein Ontology Report - hTNF PR:P01375 - http://purl.obolibrary.org/obo/PR_P01375

This page represents a class of proteins encompassing all the protein products of the TNF gene in human .

Ontology Information
PRO ID	PR:P01375 Show OBO stanza / PAF
PRO name	tumor necrosis factor (human)
Synonyms	PRO-short-label: hTNF EXACT: TNF-a (human); TNF-alpha (human); TNFa (human); cachectin (human); tumor necrosis factor ligand superfamily member 2 (human) Gene-based: TNF; TNFA; TNFSF2
Definition	A tumor necrosis factor that is encoded in the genome of human. [PRO:DNx]
Comment	Requested by=PubChem.
PRO Category	organism-gene
Parent	PR:000000134 tumor necrosis factor
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:11892, Reactome:R-HSA-66220, UniProtKB:P01375

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTNF forms found in complexes
hTNF Component Complexes PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036508 hTNF/iso:1/Phos:1 Ser-2, MOD:00046 located_in GO:0016021 integral component of membrane PMID:10205166 PR:P01375-1 hTNF/iso:1 located_in GO:0005887 integral component of plasma membrane PMID:3349526 participates_in GO:0006915 apoptotic process PMID:3856324 PR:000036504 hTNF/iso:1/Clv:1 capable_of GO:0005164 tumor necrosis factor receptor binding with PR:P19438 hTNFRSF1A PMID:14512626 capable_of GO:0042802 identical protein binding with PR:000036504 hTNF/iso:1/Clv:1 PMID:14512626 participates_in GO:0006915 apoptotic process PMID:3856324 PR:000036507 hTNF/iso:1/Myr:1 Lys-19/Lys-20, MOD:00087 located_in GO:0016021 integral component of membrane PMID:1402651 Biological Process GO Term Protein Forms & Complexes Evidence GO:0006915 apoptotic process PR:000036504 hTNF/iso:1/Clv:1 PMID:3856324 PR:P01375-1 hTNF/iso:1 PMID:3856324 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0016021 integral component of membrane PR:000036507 hTNF/iso:1/Myr:1 Lys-19/Lys-20, MOD:00087 PMID:1402651 PR:000036508 hTNF/iso:1/Phos:1 Ser-2, MOD:00046 PMID:10205166 GO:0005887 integral component of plasma membrane PR:P01375-1 hTNF/iso:1 PMID:3349526

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