Protein Ontology Report - hBUB3 PR:O43684 - http://purl.obolibrary.org/obo/PR_O43684

This page represents a class of proteins encompassing all the protein products of the BUB3 gene in human .

Ontology Information
PRO ID	PR:O43684 Show OBO stanza / PAF
PRO name	mitotic checkpoint protein BUB3 (human)
Synonyms	PRO-short-label: hBUB3 Gene-based: BUB3
Definition	A mitotic checkpoint protein BUB3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43684]
PRO Category	organism-gene
Parent	PR:000004856 mitotic checkpoint protein BUB3
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:1151, Reactome:R-HSA-141416, UniProtKB:O43684

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification

PRO ID & Category Annotation Complex Name Short Label Definition & Comment PR:O43684   5 11 organism-gene mitotic checkpoint protein BUB3 (human) hBUB3 A mitotic checkpoint protein BUB3 that is encoded in the genome of human. PR:O43684-1     organism-sequence mitotic checkpoint protein BUB3 isoform h1 (human) hBUB3/iso:h1 A mitotic checkpoint protein BUB3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43684-1. PR:000045593     organism-modification mitotic checkpoint protein BUB3 phosphorylated 2 (human) hBUB3/Phos:2 A mitotic checkpoint protein BUB3 (human) that has been phosphorylated at the position equivalent to Tyr-207 of the amino acid sequence represented by UniProtKB:O43684-1. Example: UniProtKB:O43684-1, Tyr-207, MOD:00048. Evidence=(ECO:0000006, based on PMID:24316223). Status=unreviewed PR:O43684-2     organism-sequence mitotic checkpoint protein BUB3 isoform 2 (human) hBUB3/iso:2 A mitotic checkpoint protein BUB3 isoform 2 that is encoded in the genome of human. PR:000035437    1 organism-modification mitotic checkpoint protein BUB3 phosphorylated 1 (human) hBUB3/Phos:1 A mitotic checkpoint protein BUB3 phosphorylated 1 in human. Phosphorylated on the Ser residue within the motif D[YG]ISx[IV]K. UniProtKB:O43684, Ser-18, MOD:00046. Kinase=("BUB1"; PR:O43683) PR:000035454     organism-modification mitotic checkpoint protein BUB3 unphosphorylated form (human) hBUB3/PhosRes- A mitotic checkpoint protein BUB3 unphosphorylated form in human. Kinase=("BUB1"; PR:O43683)

hBUB3 forms found in complexes
hBUB3 Component Complexes PR:O43684 hBUB3 PR:000035576 BUB1:BUB3:APC complex (human) PR:O43684 hBUB3 PR:000035567 BUB1:BUB3:MAD1L1 complex (human) PR:O43684 hBUB3 PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human) PR:O43684 hBUB3 PR:000035563 BUB1B:BUB3 complex (human) PR:O43684 hBUB3 PR:000035564 BUB1:BUB3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035437 hBUB3/Phos:1 Ser-18, MOD:00046 participates_in GO:0012501 programmed cell death increased relative to PR:000035454 hBUB3/PhosRes- PMID:20057499 PR:O43684 hBUB3 capable_of GO:0005515 protein binding with PR:O15350-5 hTP73/iso:5 PMID:20057499 capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:17785528 capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:10198256 capable_of GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 PMID:10198256 capable_of GO:0005515 protein binding with PR:O15350-3 hTP73/iso:3 PMID:20057499 capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-561804, MINT:MINT-8183848 capable_of GO:0005515 protein binding with PR:O15350-2 hTP73/iso:2 PMID:20057499 capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302961 capable_of GO:0005515 protein binding with PR:O15350-1 hTP73/iso:1 PMID:20057499 capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-718926 located_in GO:0000776 kinetochore PMID:11283619 Biological Process GO Term Protein Forms & Complexes Evidence GO:0012501 programmed cell death PR:000035437 hBUB3/Phos:1 Ser-18, MOD:00046 increased relative to PR:000035454 hBUB3/PhosRes- PMID:20057499 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000776 kinetochore PR:O43684 hBUB3 PMID:11283619

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