Protein Ontology Report - hBUB1 PR:O43683 - http://purl.obolibrary.org/obo/PR_O43683

This page represents a class of proteins encompassing all the protein products of the BUB1 gene in human .

Ontology Information
PRO ID	PR:O43683 Show OBO stanza / PAF
PRO name	mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
Synonyms	PRO-short-label: hBUB1 EXACT: BUB1A (human) Gene-based: BUB1; BUB1L
Definition	A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]
PRO Category	organism-gene
Parent	PR:000004854 mitotic checkpoint serine/threonine-protein kinase BUB1
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 6
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100052, HGNC:1148, Reactome:R-HSA-377888, UniProtKB:O43683

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification

PRO ID & Category Annotation Complex Name Short Label Definition & Comment PR:O43683   5 20 organism-gene mitotic checkpoint serine/threonine-protein kinase BUB1 (human) hBUB1 A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. PR:O43683-1     organism-sequence mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human) hBUB1/iso:h1 A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-1. PR:O43683-2     organism-sequence mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human) hBUB1/iso:h2 A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-2. PR:O43683-3     organism-sequence mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human) hBUB1/iso:h3 A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-3. PR:000035399     organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human) hBUB1/Phos:2 A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human. Kinase=("BUB1"; PR:O43683) PR:000035405    2 organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human) hBUB1/PhosRes- A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human. PR:000035407    1 organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human) hBUB1/Phos:4 A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human. PR:000035412   1 2 organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human) hBUB1/Phos:7 A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047. Kinase=("CDK1"; PR:000003271) PR:000035418     organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human) hBUB1/Phos:8 A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Phosphorylation of Thr-609 is needed by phosphorylation by Plk1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696. Kinase=("CDK1"; PR:000003271). Kinase=("PLK1"; PR:P53350) PR:000035421    4 organism-modification mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human) hBUB1/Phos:10 A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046. Kinase=("ATM"; PR:000035423)

hBUB1 forms found in complexes

hBUB1 Component Complexes PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human) PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human) PR:O43683 hBUB1 PR:000035576 BUB1:BUB3:APC complex (human) PR:O43683 hBUB1 PR:000035567 BUB1:BUB3:MAD1L1 complex (human) PR:O43683 hBUB1 PR:000035579 BUB1:unphosphoBUB1B complex (human) PR:O43683 hBUB1 PR:000035577 BUB1:phosphoBUB1B complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:O43683 hBUB1 capable_of GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 PMID:10198256 capable_of GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-723200 capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:11792804 capable_of GO:0005515 protein binding with PR:P53350 hPLK1 BioGRID:BG-718371 capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:10198256, PMID:15525512 capable_of GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:19252416 capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302960 capable_of GO:0004672 protein kinase activity PMID:10198256 located_in GO:0000776 kinetochore PMID:20624902 located_in GO:0000939 inner kinetochore PMID:11792804 located_in GO:0000940 outer kinetochore PMID:11792804, PMID:16760428 participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:16760428 participates_in GO:0007062 sister chromatid cohesion PMID:16580887 participates_in GO:0043069 negative regulation of programmed cell death PMID:20057499 participates_in GO:0007059 chromosome segregation PMID:16580887 participates_in GO:0043066 negative regulation of apoptotic process PMID:19252416 participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:16580887 participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 participates_in GO:0031577 spindle checkpoint signaling PMID:15525512 participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 PR:000035412 hBUB1/Phos:7 Ser-593, MOD:00046|Thr-609, MOD:00047 capable_of GO:0005515 protein binding increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP PMID:16760428 participates_in GO:0034501 protein localization to kinetochore PMID:16760428 PR:000035407 hBUB1/Phos:4 capable_of GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:15525512 PR:000035405 hBUB1/PhosRes- capable_of NOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428 located_in GO:0000776 kinetochore PMID:16760428 PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 capable_of GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:22071147 located_in GO:0035861 site of double-strand break PMID:22071147 participates_in GO:0031577 spindle checkpoint signaling PMID:22099307 participates_in GO:0006281 DNA repair PMID:22071147 Biological Process GO Term Protein Forms & Complexes Evidence GO:0006281 DNA repair PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 PMID:22071147 GO:0007059 chromosome segregation PR:O43683 hBUB1 PMID:16580887 GO:0034501 protein localization to kinetochore PR:000035412 hBUB1/Phos:7 Ser-593, MOD:00046|Thr-609, MOD:00047 PMID:16760428 GO:0043069 negative regulation of programmed cell death PR:O43683 hBUB1 PMID:20057499 GO:0043066 negative regulation of apoptotic process PR:O43683 hBUB1 PMID:19252416 GO:0031577 spindle checkpoint signaling PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 PMID:22099307 PR:O43683 hBUB1 PMID:15525512 GO:0071459 protein localization to chromosome, centromeric region PR:O43683 hBUB1 PMID:16760428 PR:O43683 hBUB1 PMID:16580887 PR:O43683 hBUB1 PMID:21658950 PR:O43683 hBUB1 PMID:21658950 GO:0007062 sister chromatid cohesion PR:O43683 hBUB1 PMID:16580887 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000940 outer kinetochore PR:O43683 hBUB1 PMID:11792804, PMID:16760428 GO:0035861 site of double-strand break PR:000035421 hBUB1/Phos:10 Ser-314, MOD:00046 PMID:22071147 GO:0000939 inner kinetochore PR:O43683 hBUB1 PMID:11792804 GO:0000776 kinetochore PR:000035405 hBUB1/PhosRes- PMID:16760428 PR:O43683 hBUB1 PMID:20624902

top