Protein Ontology Report - hDVL2 PR:O14641 - http://purl.obolibrary.org/obo/PR_O14641

This page represents a class of proteins encompassing all the protein products of the DVL2 gene in human .

Ontology Information
PRO ID	PR:O14641 Show OBO stanza / PAF
PRO name	segment polarity protein dishevelled homolog DVL-2 (human)
Synonyms	PRO-short-label: hDVL2 EXACT: DSH homolog 2 (human); dishevelled-2 (human) Gene-based: DVL2
Definition	A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human. [PMID:20823832, PRO:KER]
PRO Category	organism-gene
Parent	PR:000006767 segment polarity protein dishevelled homolog DVL-2
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 4
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:3086, Reactome:R-HSA-201694, UniProtKB:O14641

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification

PRO ID & Category Annotation Complex Name Short Label Definition & Comment PR:O14641    13 organism-gene segment polarity protein dishevelled homolog DVL-2 (human) hDVL2 A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human. PR:000047225     organism-modification segment polarity protein dishevelled homolog DVL-2 phosphorylated form (human) hDVL2/PhosRes+ A segment polarity protein dishevelled homolog DVL-2 (human) that includes at least one phosphorylated residue. UniProtKB:O14641, MOD:00696. PR:000047226     organism-modification segment polarity protein dishevelled homolog DVL-2 ubiquitinated form (human) hDVL2/UbiqLys+ A segment polarity protein dishevelled homolog DVL-2 (human) that includes at least one ubiquitinated lysine. UniProtKB:O14641, MOD:01148. PR:O14641-1     organism-sequence segment polarity protein dishevelled homolog DVL-2 isoform 1 (human) hDVL2/iso:1 A segment polarity protein dishevelled homolog DVL-2 isoform 1 that is encoded in the genome of human. PR:000035550    2 organism-modification segment polarity protein dishevelled homolog DVL-2 unphosphorylated form (human) hDVL2/PhosRes- A segment polarity protein dishevelled homolog DVL-2 unphosphorylated form in human. PR:000035549    2 organism-modification segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 (human) hDVL2/Phos:1 A segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 in human. UniProtKB:O14641, Thr-206, MOD:00047. Kinase=("PLK1"; PR:P53350)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035550 hDVL2/PhosRes- located_in GO:0000776 kinetochore PMID:20823832 participates_in GO:0031577 spindle checkpoint signaling PMID:20823832 PR:000035549 hDVL2/Phos:1 Thr-206, MOD:00047 participates_in GO:0051294 establishment of spindle orientation increased relative to PR:000035550 hDVL2/PhosRes- PMID:20823832 participates_in GO:0031577 spindle checkpoint signaling PMID:20823832 PR:O14641 hDVL2 capable_of GO:0005515 protein binding with PR:P33981 hTTK PMID:20823832 capable_of GO:0005515 protein binding with PR:P53350 hPLK1 PMID:20823832 capable_of GO:0005515 protein binding with PR:P25054 hAPC PMID:20823832 located_in GO:0000776 kinetochore PMID:20823832 located_in GO:0000922 spindle pole PMID:20823832 located_in GO:0005819 spindle PMID:20823832 located_in GO:0032154 cleavage furrow PMID:20823832 participates_in GO:0008608 attachment of spindle microtubules to kinetochore PMID:20823832 participates_in GO:0034501 protein localization to kinetochore PMID:20823832 participates_in GO:0034501 protein localization to kinetochore PMID:20823832 participates_in GO:0033674 positive regulation of kinase activity PMID:20823832 participates_in GO:0051310 metaphase plate congression PMID:20823832 participates_in GO:0031589 cell-substrate adhesion PMID:20823832 Biological Process GO Term Protein Forms & Complexes Evidence GO:0031589 cell-substrate adhesion PR:O14641 hDVL2 PMID:20823832 GO:0051294 establishment of spindle orientation PR:000035549 hDVL2/Phos:1 Thr-206, MOD:00047 increased relative to PR:000035550 hDVL2/PhosRes- PMID:20823832 GO:0008608 attachment of spindle microtubules to kinetochore PR:O14641 hDVL2 PMID:20823832 GO:0033674 positive regulation of kinase activity PR:O14641 hDVL2 PMID:20823832 GO:0034501 protein localization to kinetochore PR:O14641 hDVL2 PMID:20823832 PR:O14641 hDVL2 PMID:20823832 GO:0031577 spindle checkpoint signaling PR:000035549 hDVL2/Phos:1 Thr-206, MOD:00047 PMID:20823832 PR:000035550 hDVL2/PhosRes- PMID:20823832 GO:0051310 metaphase plate congression PR:O14641 hDVL2 PMID:20823832 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005819 spindle PR:O14641 hDVL2 PMID:20823832 GO:0000922 spindle pole PR:O14641 hDVL2 PMID:20823832 GO:0000776 kinetochore PR:000035550 hDVL2/PhosRes- PMID:20823832 PR:O14641 hDVL2 PMID:20823832 GO:0032154 cleavage furrow PR:O14641 hDVL2 PMID:20823832

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