Protein Ontology Report - chick-MYD88 PR:A5HNF6 - http://purl.obolibrary.org/obo/PR_A5HNF6

This page represents a class of proteins encompassing all the protein products of the MYD88 gene in chicken .

Ontology Information
PRO ID	PR:A5HNF6 Show OBO stanza / PAF
PRO name	myeloid differentiation primary response protein MyD88 (chicken)
Synonyms	PRO-short-label: chick-MYD88 Gene-based: MYD88; RCJMB04_14h3
Definition	A myeloid differentiation primary response protein MyD88 that is encoded in the genome of chicken. [OMA:A5HNF6, PMID:18582498, PRO:CNA]
Comment	Note: The chicken MyD88 gene was cloned and its expression was detected in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus and bursa. Over-expression of chicken MyD88 significantly stimulated the activation of NF-kB in vitro.
PRO Category	organism-gene
Parent	PR:000001740 myeloid differentiation primary response protein MyD88
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 0 organism-modification 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	CGNC:4445, Reactome:R-GGA-433900, Reactome:R-GGA-433987, Reactome:R-GGA-573258, UniProtKB:A5HNF6

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

chick-MYD88 forms found in complexes
chick-MYD88 Component Complexes PR:000001740 MYD88 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor PR:A5HNF6 chick-MYD88 PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000001740 MYD88 has_part Pfam:PF01582 TIR domain has_part Pfam:PF00531 Death domain PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken) located_in GO:0005886 plasma membrane Reactome:REACT_26615 participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25089 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_25089 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken) Reactome:REACT_25089 GO:0034142 toll-like receptor 4 signaling pathway PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken) Reactome:REACT_25089 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005886 plasma membrane PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken) Reactome:REACT_26615

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