Entry Report [PIR] - PR:000045369

Protein Ontology Report - hSIAH1/iso:1/UnPhos:1

PR:000045369 - http://purl.obolibrary.org/obo/PR_000045369

Protein Forms Annotations

Ontology Information

PRO ID

PR:000045369 Show OBO stanza / PAF

PRO name

E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human)

Synonyms

PRO-short-label:	hSIAH1/iso:1/UnPhos:1
PRO-proteoform-std:	UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291

Definition

An E3 ubiquitin-protein ligase SIAH1 isoform 1 (human) that lacks phosphorylation at Tyr-100 and Tyr-126. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291. [PRO:JAN]

PRO Category

organism-modification

Parent

PR:Q8IUQ4-1 E3 ubiquitin-protein ligase SIAH1 isoform 1 (human)

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000045369 hSIAH1/iso:1/UnPhos:1 Tyr-100/Tyr-126, PR:000026291	capable_of	GO:0005515 protein binding with PR:Q69ZI1 mSH3RF1	PMID:16230351
	participates_in	GO:0070304 positive regulation of stress-activated protein kinase signaling cascade	PMID:16230351
	participates_in	GO:0043525 positive regulation of neuron apoptotic process	PMID:16230351

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade	PR:000045369 hSIAH1/iso:1/UnPhos:1 Tyr-100/Tyr-126, PR:000026291	PMID:16230351
GO:0043525 positive regulation of neuron apoptotic process	PR:000045369 hSIAH1/iso:1/UnPhos:1 Tyr-100/Tyr-126, PR:000026291	PMID:16230351

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