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Protein Ontology Report - traf6:ticam1:activated TLR3 complex

PR:000037343 - http://purl.obolibrary.org/obo/PR_000037343
Ontology Information
PRO ID PR:000037343 Show OBO stanza / PAF
PRO name traf6:ticam1:activated TLR3 complex
Synonyms
RELATED: activated TLR3:TRIF:TRAF6
Definition A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), TICAM1 (TRIF) and TRAF6. [Reactome:R-HSA-936976]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037344 PR:Q9Y4K3 TNF receptor-associated factor 6 (human) hTRAF6 A TNF receptor-associated factor 6 that is encoded in the genome of human. [PRO:CNx, UniProtKB:Q9Y4K3] 1
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037471 PR:P70196 TNF receptor-associated factor 6 (mouse) mTRAF6 A TNF receptor-associated factor 6 that is encoded in the genome of mouse. [OMA:P70196, PRO:CNA] 1
PR:Q80UF7 TIR domain-containing adapter molecule 1 (mouse) mTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of mouse. [OMA:Q80UF7, PRO:CNA] 2
PR:000037789 Toll-like receptor 3, signal peptide removed form (mouse) mTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905. [ECO:0000250, PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037344
traf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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