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Protein Ontology Report - DenV-NS2BNS3

PR:000036829 - http://purl.obolibrary.org/obo/PR_000036829
Ontology Information
PRO ID PR:000036829 Show OBO stanza / PAF
PRO name NS2B-NS3 complex
Synonyms
PRO-short-label: DenV-NS2BNS3
EXACT: NS2B-NS3 protease; NS2B-NS3 protease complex; NS2B-NS3pro
Definition A protein-containing complex consisting of NS3 which has a serine protease domain that requires the conserved hydrophilic domain of NS2B for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form at sites following two basic amino acids. [PMID:10744671, PRO:ES]
Comment Requested by=IDODEN.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000036829 PR:000036828 NS3 DenV-NS3 A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain. [PMID:10744671, PRO:ES] 1
PR:000036827 NS2B DenV-NS2B A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form. [PMID:10744671, PRO:ES] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000036829
NS2B-NS3 complex
capable_of GO:0008236 serine-type peptidase activity PMID:10744671
capable_of GO:0008236 serine-type peptidase activity PMID:23511634
participates_in GO:0019082 viral protein processing PMID:10744671
participates_in GO:0019082 viral protein processing PMID:23511634
participates_in GO:0016540 protein autoprocessing PMID:23511634
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0019082 viral protein processing PR:000036829 NS2B-NS3 complex

PMID:10744671
PR:000036829 NS2B-NS3 complex

PMID:23511634
GO:0016540 protein autoprocessing PR:000036829 NS2B-NS3 complex

PMID:23511634

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