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Protein Ontology Report - MAD3

PR:000035499 - http://purl.obolibrary.org/obo/PR_000035499
Ontology Information
PRO ID PR:000035499 Show OBO stanza / PAF
PRO name spindle assembly checkpoint component MAD3
Synonyms
PRO-short-label: MAD3
BROAD: Mitotic MAD3 protein
Definition A protein that is a translation product of the yeast MAD3 gene or a 1:1 ortholog thereof. MAD3 is related to BUB1 and BUB1B, all of which contain the Mad3/BUB1 homology region 1 (Pfam:PF00831), but MAD3 lacks the C-terminal Protein kinase domain (Pfam:PF00069). [PMID:15970700, PMID:22698286, PRO:KER]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 0 organism-sequence 0
modification 3 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

MAD3 forms found in complexes
MAD3 Component Complexes
PR:O59767 Spom972h-MAD3 PR:000035574 MAD2:MAD3 complex (Schizosaccharomyces pombe 972h-)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035499
MAD3
has_part Pfam:PF08311 Mad3/BUB1 homology region 1 PMID:22698286
PR:O59767
Spom972h-MAD3
capable_of GO:0005515 protein binding with PR:O14417 Spom972h-MAD2L1 PMID:12676091
located_in GO:0000776 kinetochore PMID:12676091
PR:000035503
yMAD3/Phos:2
Ser-303/Ser-337, MOD:00046 		participates_in GO:0031577 spindle checkpoint signaling increased relative to PR:000035506 yMAD3/PhosRes- PMID:17504936
PR:P47074
yMAD3
capable_of GO:0005515 protein binding with PR:P26449 yBUB3 IntAct:EBI-1269169
capable_of GO:0005515 protein binding with PR:P26309 yCDC20 IntAct:EBI-1269178
capable_of GO:0005515 protein binding with PR:P40958 yMAD2L1 IntAct:EBI-1269217
participates_in GO:0006974 cellular response to DNA damage stimulus PMID:15514023
participates_in GO:0031577 spindle checkpoint signaling PMID:15970700
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0031577 spindle checkpoint signaling PR:000035503 yMAD3/Phos:2
Ser-303/Ser-337, MOD:00046
increased relative to PR:000035506 yMAD3/PhosRes- 		PMID:17504936
PR:P47074 yMAD3

PMID:15970700
GO:0006974 cellular response to DNA damage stimulus PR:P47074 yMAD3

PMID:15514023
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:O59767 Spom972h-MAD3

PMID:12676091

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