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Protein Ontology Report - hCTNNB1/iso:1/Phos:1

PR:000030192 - http://purl.obolibrary.org/obo/PR_000030192
Ontology Information
PRO ID PR:000030192 Show OBO stanza / PAF
PRO name catenin beta-1 isoform 1 phosphorylated 1 (human)
Synonyms
PRO-short-label: hCTNNB1/iso:1/Phos:1
PRO-proteoform-std: UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046
Definition A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046. [PMID:22369945, PRO:IC]
Comment Kinase=("PAK1"; PR:000035776). Kinase=("PKA"; PR:000029188).
PRO Category organism-modification
Parent PR:000030191 catenin beta-1 isoform 1 phosphorylated 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000030192
hCTNNB1/iso:1/Phos:1
Ser-663/Ser-675, MOD:00046 		capable_of GO:0003713 transcription coactivator activity increased relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
participates_in GO:0016055 Wnt signaling pathway PMID:22369945
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0016055 Wnt signaling pathway PR:000030192 hCTNNB1/iso:1/Phos:1
Ser-663/Ser-675, MOD:00046
PMID:22369945

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