Protein Ontology Report - integrin alphaPR:000025796 - http://purl.obolibrary.org/obo/PR_000025796 |
Ontology Information | |
---|---|
PRO ID | PR:000025796 Show OBO stanza |
PRO name | integrin alpha |
Definition | A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif. [PMID:19693543] |
Comment | Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. |
PRO Category | family |
Parent | PR:000000001 protein |
Term Hierarchy Visualization | DAG OLS Cytoscape |
top