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Protein Ontology Report - EGFR

PR:000006933 - http://purl.obolibrary.org/obo/PR_000006933
Ontology Information
PRO ID PR:000006933 Show OBO stanza / PAF
PRO name epidermal growth factor receptor
Synonyms
PRO-short-label: EGFR
EXACT: proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
Gene-based: ERBB; ERBB1; HER1
Definition An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000001812 EGF receptor type tyrosine-protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 5
modification 3 organism-modification 26
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

EGFR forms found in complexes
EGFR Component Complexes
PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049851
hEGFR/SigPep-/Phos:4
Ser-768, MOD:00046 		capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170
PR:000049849
hEGFR/SigPep-/Phos:3
Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 		capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
capable_of GO:0005515 protein binding decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 with PR:P00533 hEGFR PMID:10347170
PR:000027479
hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048 		located_in GO:0005634 nucleus PMID:18789131
participates_in GO:0034504 protein localization to nucleus PMID:18789131
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034504 protein localization to nucleus PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048
PMID:18789131
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
Tyr-869, MOD:00048
PMID:18789131

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