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Protein Ontology Report - APC

PR:000004122 - http://purl.obolibrary.org/obo/PR_000004122
Ontology Information
PRO ID PR:000004122 Show OBO stanza / PAF
PRO name adenomatous polyposis coli protein
Synonyms
PRO-short-label: APC
EXACT: deleted in polyposis 2.5; protein APC
Gene-based: DP2.5
Definition A protein that is a translation product of the human APC gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 7
modification 5 organism-modification 8
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment
PR:000004122    
gene		adenomatous polyposis coli proteinAPCA protein that is a translation product of the human APC gene or a 1:1 ortholog thereof.
PR:P25054   1 8
organism-gene		adenomatous polyposis coli protein (human)hAPCAn adenomatous polyposis coli protein that is encoded in the genome of human.
PR:P70039    
organism-gene		adenomatous polyposis coli homolog (frog)frog-APCAn adenomatous polyposis coli protein that is encoded in the genome of frog.
PR:P70478    
organism-gene		adenomatous polyposis coli protein (rat)rAPCAn adenomatous polyposis coli protein that is encoded in the genome of rat.
PR:Q61315    
organism-gene		adenomatous polyposis coli protein (mouse)mAPCAn adenomatous polyposis coli protein that is encoded in the genome of mouse.
PR:000030182    
modification		adenomatous polyposis coli protein phosphorylated 1APC/Phos:1An adenomatous polyposis coli protein that has been phosphorylated in the middle and the C-terminal regions by the BUB1:BUB3 complex.
Note: In vitro
PR:000030184    
modification		adenomatous polyposis coli protein phosphorylated 2APC/Phos:2An adenomatous polyposis coli protein that has been phosphorylated by the Bub1b-Bub3 complex.
Note: In vitro
PR:000030186    
modification		adenomatous polyposis coli protein phosphorylated 3APC/Phos:3An adenomatous polyposis coli protein that has been phosphorylated by GSK3B kinase.
Note: In vitro
PR:000030188    
modification		adenomatous polyposis coli protein phosphorylated 4APC/Phos:4An adenomatous polyposis coli protein that has been phosphorylated by both the Gsk3b and the Bub1.
Note: In vitro
PR:000035394    
modification		adenomatous polyposis coli protein phosphorylated 6APC/Phos:6An adenomatous polyposis coli protein that has been phosphorylated by Bub1B.

APC forms found in complexes
APC Component Complexes
PR:000035395 frog-APC/Phos:6 PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:P25054
hAPC
capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957
capable_of GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832
capable_of GO:0008017 microtubule binding PMID:11283619
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619
located_in GO:0000776 kinetochore PMID:11283619
participates_in NOT GO:0031577 spindle checkpoint signaling PMID:11283619
participates_in GO:0007059 chromosome segregation PMID:11283619
PR:000035398
BUB1B:APC:EB1 complex (frog)
participates_in GO:0051310 metaphase plate congression PMID:17709426
Biological Process GO Term Protein Forms & Complexes Evidence
NOT GO:0031577 spindle checkpoint signaling PR:P25054 hAPC

PMID:11283619
GO:0051310 metaphase plate congression PR:000035398 BUB1B:APC:EB1 complex (frog)

PMID:17709426
GO:0007059 chromosome segregation PR:P25054 hAPC

PMID:11283619
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P25054 hAPC

PMID:11283619

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