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Protein Ontology Report - PRKCB

PR:000003059 - http://purl.obolibrary.org/obo/PR_000003059
Ontology Information
PRO ID PR:000003059 Show OBO stanza / PAF
PRO name protein kinase C beta type
Synonyms
PRO-short-label: PRKCB
EXACT: PKC-B; PKC-beta
Gene-based: PKCB; PRKCB1
Definition A conventional protein kinase C that is a translation product of the human PRKCB gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000003057 conventional protein kinase C
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 2 organism-sequence 6
modification 2 organism-modification 16
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049853
hPRKCB/iso:Beta-II/InitMet-/Phos:1
Thr-500, MOD:00047 		capable_of GO:0004674 protein serine/threonine kinase activity increased relative to PR:000049854 hPRKCB/iso:Beta-II/InitMet-/UnPhos:1 PMID:8749392
located_in GO:0005886 plasma membrane PMID:9756933
located_in GO:0005737 cytoplasm PMID:9756933
PR:000049855
hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046 		capable_of GO:0005509 calcium ion binding increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
capable_of GO:0001786 phosphatidylserine binding increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_in GO:0005737 cytoplasm increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
participates_in GO:0006468 protein phosphorylation increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
PR:P05771-2
hPRKCB/iso:Beta-II
located_in GO:0016020 membrane MGI:3847400, PMID:18323529
participates_in GO:0001666 response to hypoxia MGI:3847400, PMID:18323529
PR:P05771-1
hPRKCB/iso:Beta-I
located_in GO:0016020 membrane MGI:3847400, PMID:18323529
participates_in NOT GO:0001666 response to hypoxia MGI:3847400, PMID:18323529
Biological Process GO Term Protein Forms & Complexes Evidence
NOT GO:0001666 response to hypoxia PR:P05771-1 hPRKCB/iso:Beta-I

MGI:3847400, PMID:18323529
GO:0006468 protein phosphorylation PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 		PMID:8749392
GO:0001666 response to hypoxia PR:P05771-2 hPRKCB/iso:Beta-II

MGI:3847400, PMID:18323529
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:P05771-1 hPRKCB/iso:Beta-I

MGI:3847400, PMID:18323529
PR:P05771-2 hPRKCB/iso:Beta-II

MGI:3847400, PMID:18323529
GO:0005737 cytoplasm PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
Thr-500, MOD:00047
PMID:9756933
PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 		PMID:9756933
GO:0005886 plasma membrane PR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1
Thr-500, MOD:00047
PMID:9756933

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