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Protein Ontology Report - BAD

PR:000002184 - http://purl.obolibrary.org/obo/PR_000002184
Ontology Information
PRO ID PR:000002184 Show OBO stanza / PAF
PRO name Bcl2-associated agonist of cell death
Synonyms
PRO-short-label: BAD
EXACT: Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2 antagonist of cell death; Bcl2-L-8; bcl-XL/Bcl-2-associated death promoter
Gene-based: BBC6; BCL2L8
Definition A protein that is a translation product of the human BAD gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 3 organism-sequence 5
modification 13 organism-modification 15
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000044747
mBAD/iso:1/UnMod
capable_of GO:0005515 protein binding with PR:P04049 hRAF1 PMID:17011751
capable_of GO:0005515 protein binding with PR:P06803-2 mPIM1/iso:2 PMID:15280015
capable_of GO:0005515 protein binding with PR:P15056 hBRAF PMID:17011751
capable_of GO:0005515 protein binding with PR:Q04759 hPRKCQ PMID:17011751
located_in GO:0031966 mitochondrial membrane PMID:15280015
participates_in GO:0006915 apoptotic process PMID:15280015
PR:O35147-2
rBAD/iso:Beta
capable_of GO:0005515 protein binding with PR:O88996-1 rBCL2L2/iso:1 PMID:11161472
participates_in GO:0043525 positive regulation of neuron apoptotic process PMID:11161472
PR:O35147-1
rBAD/iso:Alpha
capable_of GO:0005515 protein binding with PR:O88996-1 rBCL2L2/iso:1 PMID:11161472
participates_in GO:0043525 positive regulation of neuron apoptotic process PMID:11161472
PR:000044749
hBAD/iso:2/UnMod
capable_of GO:0005515 protein binding with PR:Q07817-1 hBCL2L1/iso:1 PMID:10195903
located_in GO:0005739 mitochondrion PMID:10195903
PR:000044748
rBAD/iso:1/UnMod
capable_of GO:0019902 phosphatase binding decreased relative to PR:000026134 rBAD/iso:1/Phos:3 with PR:P63329 rPPP3CA PMID:10195903
capable_of GO:0005515 protein binding with PR:P53563-1 rBcl2l1/iso:Bcl-X(L) PMID:10195903
located_in GO:0005739 mitochondrion PMID:10195903
PR:000026133
mBAD/iso:1/Phos:2
Ser-112/Ser-136/Ser-155, MOD:00046 		capable_of NOT GO:0005515 protein binding with PR:Q07817-1 hBCL2L1/iso:1 PMID:10949026
capable_of GO:0005515 protein binding with PR:P63101-1 mYWHAZ/iso:1 PMID:10949026
capable_of GO:0005515 protein binding decreased relative to PR:000037809 mBAD/iso:1/UnPhos:1 with PR:Q64373-1 mBCL2L1/iso:Bcl-X(L) PMID:16403219
capable_of GO:0005515 protein binding with PR:000003237 fam:14-3-3 PMID:16403219
participates_in GO:0043066 negative regulation of apoptotic process PMID:10949026
PR:000026134
rBAD/iso:1/Phos:3
Ser-112, MOD:00046 		capable_of GO:0019902 phosphatase binding with PR:P63329 rPPP3CA PMID:10195903
capable_of GO:0005515 protein binding decreased relative to PR:000002843 BAD/iso:1/UnMod with PR:P53563-1 rBcl2l1/iso:Bcl-X(L) PMID:10195903
located_in GO:0005829 cytosol PMID:10195903
PR:000026135
mBAD/iso:1/Phos:4
Thr-201, MOD:00047 		capable_of GO:0005515 protein binding decreased relative to PR:000002843 BAD/iso:1/UnMod with PR:Q64373-1 mBCL2L1/iso:Bcl-X(L) PMID:14967141
participates_in GO:0043066 negative regulation of apoptotic process PMID:14967141
PR:000026136
mBAD/iso:1/Phos:5
Ser-136, MOD:00046 		capable_of GO:0005515 protein binding with PR:P63101 mYWHAZ PMID:12049737
PR:000026137
mBAD/iso:1/Phos:6
Ser-128/Ser-136, MOD:00046 		participates_in GO:0051402 neuron apoptotic process PMID:12049737
PR:000026167
mBAD/iso:1/Phos:1
Ser-112/Ser-136, MOD:00046 		capable_of GO:0005515 protein binding with PR:Q07817-1 hBCL2L1/iso:1 PMID:10949026
capable_of GO:0005515 protein binding decreased relative to PR:000026136 mBAD/iso:1/Phos:5 with PR:P63101 mYWHAZ PMID:12049737
capable_of GO:0005515 protein binding with PR:P62258-1 hYWHAE/iso:1 PMID:10490655
capable_of GO:0005515 protein binding with PR:Q9CQV8 mYWHAB PMID:10490655
PR:000026139
mBAD/iso:1/Phos:8
Ser-155, MOD:00046 		capable_of GO:0071889 14-3-3 protein binding with PR:P61982 mYWHAG PMID:10880354
PR:000026140
hBAD/iso:2/Phos:1
Ser-75/Ser-99, MOD:00046 		capable_of GO:0071889 14-3-3 protein binding with PR:P63101 mYWHAZ PMID:16932738
capable_of GO:0005829 cytosol PMID:16932738
capable_of GO:0019902 phosphatase binding with PR:Q08209 hPPP3CA PMID:10195903
capable_of GO:0005515 protein binding decreased relative to PR:000002844 BAD/iso:2/UnMod with PR:Q07817-1 hBCL2L1/iso:1 PMID:10195903
located_in GO:0005829 cytosol PMID:10195903
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000026133 mBAD/iso:1/Phos:2
Ser-112/Ser-136/Ser-155, MOD:00046
PMID:10949026
PR:000026135 mBAD/iso:1/Phos:4
Thr-201, MOD:00047
PMID:14967141
GO:0051402 neuron apoptotic process PR:000026137 mBAD/iso:1/Phos:6
Ser-128/Ser-136, MOD:00046
PMID:12049737
GO:0006915 apoptotic process PR:000044747 mBAD/iso:1/UnMod

PMID:15280015
GO:0043525 positive regulation of neuron apoptotic process PR:O35147-1 rBAD/iso:Alpha

PMID:11161472
PR:O35147-2 rBAD/iso:Beta

PMID:11161472
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000026134 rBAD/iso:1/Phos:3
Ser-112, MOD:00046
PMID:10195903
PR:000026140 hBAD/iso:2/Phos:1
Ser-75/Ser-99, MOD:00046
PMID:10195903
GO:0031966 mitochondrial membrane PR:000044747 mBAD/iso:1/UnMod

PMID:15280015
GO:0005739 mitochondrion PR:000044748 rBAD/iso:1/UnMod

PMID:10195903
PR:000044749 hBAD/iso:2/UnMod

PMID:10195903

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