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Protein Ontology Report - IRF7

PR:000002049 - http://purl.obolibrary.org/obo/PR_000002049
Ontology Information
PRO ID PR:000002049 Show OBO stanza / PAF
PRO name interferon regulatory factor 7
Synonyms
PRO-short-label: IRF7
EXACT: IRF-7
Definition An interferon regulatory factor 3-9 that is a translation product of the human IRF7 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000001863 interferon regulatory factor 3-9
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 4
modification 4 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRF7 forms found in complexes
IRF7 Component Complexes
PR:000027082 hIRF7/iso:1/Phos:1 PR:000027086 IRF7-P:IRF7-P complex (human)
PR:000027082 hIRF7/iso:1/Phos:1 PR:000027084 IRF3-P:IRF7-P complex (human)
PR:000028704 hIRF7/UnMod PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028704 hIRF7/UnMod PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028704 hIRF7/UnMod PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028704 hIRF7/UnMod PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037791
hIRF7/iso:1/UnPhos:1
Ser-477/Ser-479, PR:000026291 		located_in GO:0005737 cytoplasm Reactome:REACT_21735
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000027086
IRF7-P:IRF7-P complex (human)
capable_of GO:0003700 DNA-binding transcription factor activity PMID:11073981
located_in GO:0005654 nucleoplasm Reactome:REACT_21689
participates_in GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus Reactome:REACT_7146
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027086 IRF7-P:IRF7-P complex (human)

Reactome:REACT_6809
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus PR:000027086 IRF7-P:IRF7-P complex (human)

Reactome:REACT_7146
GO:0034142 toll-like receptor 4 signaling pathway PR:000027086 IRF7-P:IRF7-P complex (human)

Reactome:REACT_6894
GO:0034138 toll-like receptor 3 signaling pathway PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005654 nucleoplasm PR:000027086 IRF7-P:IRF7-P complex (human)

Reactome:REACT_21689
GO:0010008 endosome membrane PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0005737 cytoplasm PR:000037791 hIRF7/iso:1/UnPhos:1
Ser-477/Ser-479, PR:000026291
Reactome:REACT_21735

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