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Protein Ontology Report - PDGFRB

PR:000002035 - http://purl.obolibrary.org/obo/PR_000002035
Ontology Information
PRO ID PR:000002035 Show OBO stanza / PAF
PRO name beta-type platelet-derived growth factor receptor
Synonyms
PRO-short-label: PDGFRB
EXACT: CD140 antigen-like family member B; CD140b; PDGF-R-beta; PDGFR-1; PDGFR-beta; beta platelet-derived growth factor receptor; platelet-derived growth factor receptor 1
Gene-based: PDGFR1
RELATED: Pdgfr
Definition A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRB gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000001810 CSF-1/PDGF receptor-type tyrosine-protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 2 organism-sequence 4
modification 4 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049848
hPDGFRB/SigPep-/UnPhos:2
Tyr-857, PR:000026291 		participates_in GO:0038083 peptidyl-tyrosine autophosphorylation PMID:9642269
PR:000049847
hPDGFRB/SigPep-/Phos:3
Tyr-857, MOD:00048|Ser-1104, MOD:00046 		capable_of GO:0005515 protein binding decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 with PR:O14745 hSLC9A3R1 PMID:15271984
capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
participates_in GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
PR:000049846
hPDGFRB/SigPep-/Phos:2
Tyr-857, MOD:00048 		capable_of GO:0004713 protein tyrosine kinase activity PMID:15994317, PMID:9642269
capable_of GO:0005515 protein binding increased relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 with PR:P20936 hRASA1 PMID:1653029
participates_in GO:0018108 peptidyl-tyrosine phosphorylation increased relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 PMID:1653029, PMID:9642269
PR:000002035
PDGFRB
has_part Pfam:PF07714 Protein tyrosine and serine/threonine kinase
has_part Pfam:PF00047 Immunoglobulin domain
has_part Pfam:PF07679 Immunoglobulin I-set domain
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0018108 peptidyl-tyrosine phosphorylation PR:000049846 hPDGFRB/SigPep-/Phos:2
Tyr-857, MOD:00048
increased relative to PR:000049848 hPDGFRB/SigPep-/UnPhos:2 		PMID:1653029, PMID:9642269
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling PR:000049847 hPDGFRB/SigPep-/Phos:3
Tyr-857, MOD:00048|Ser-1104, MOD:00046
decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 		PMID:15271984
GO:0038083 peptidyl-tyrosine autophosphorylation PR:000049848 hPDGFRB/SigPep-/UnPhos:2
Tyr-857, PR:000026291
PMID:9642269

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