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Protein Ontology Report - IKBKB

PR:000001776 - http://purl.obolibrary.org/obo/PR_000001776
Ontology Information
PRO ID PR:000001776 Show OBO stanza / PAF
PRO name inhibitor of nuclear factor kappa-B kinase subunit beta
Synonyms
PRO-short-label: IKBKB
EXACT: I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IkBKB; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB
Gene-based: IKKB
Definition An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human IKBKB gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001774 inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 0 organism-sequence 5
modification 1 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IKBKB forms found in complexes
IKBKB Component Complexes
PR:000035831 hIKBKB/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:000036115 mIKBKB/Phos:1 PR:000036119 activated IkappaB kinase complex (mouse)
PR:O14920 hIKBKB PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:O14920 hIKBKB PR:000026457 IkappaB kinase complex (human)
PR:O14920 hIKBKB PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:O88351 mIKBKB PR:000036118 IkappaB kinase complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000026457
IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035833
activated IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034142 toll-like receptor 4 signaling pathway PR:000026457 IkappaB kinase complex (human)

Reactome:REACT_6894
PR:000035833 activated IkappaB kinase complex (human)

Reactome:REACT_6894
GO:0034138 toll-like receptor 3 signaling pathway PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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