| PRO ID |
PR:000001045
Show OBO stanza
|
| PRO name |
cftr isoform 1 |
| Synonyms |
| PRO-short-label: |
CFTR/iso:1 |
| EXACT: |
cystic fibrosis transmembrane conductance regulator isoform 1 |
|
| Definition |
A cystic fibrosis transmembrane conductance regulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13569-1 or a 1:1 ortholog thereof.
[PMID:9922375, PRO:CNA, PRO:DAN]
|
| Comment |
Note: This isoform contains an intracellular regulatory domain (R-domain) that, when unphosphorylated, inhibits CFTR. Phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux. |
| PRO Category |
sequence |
| Parent |
PR:000001044 cystic fibrosis transmembrane conductance regulator |
| Term Hierarchy Visualization |
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 OLS
Cytoscape
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