| PRO ID |
PR:000000909
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/ PAF
|
| PRO name |
voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human) |
| Synonyms |
| PRO-short-label: |
hKCNQ2/var:R207W |
| EXACT: |
voltage-gated potassium channel subunit KCNQ2 sequence variant 2 (human) |
| PRO-proteoform-std: |
UniProtKB:O43526-1, Arg-207, CHEBI:29954 |
|
| Definition |
A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Arg-207 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Arg-207, CHEBI:29954.
[PMID:11572947, PRO:CNA, PRO:DAN]
|
| Comment |
Note: This mutation neutralizes a charged amino acid in the S4 voltage-sensor segment of KCNQ2, and leads to a shift of voltage-dependent activation of KCNQ2 and a dramatic slowing of activation upon depolarization. |
| PRO Category |
organism-sequence |
| Parent |
PR:O43526 potassium voltage-gated channel subfamily KQT member 2 (human) |
| Term Hierarchy Visualization |
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