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Protein Ontology Report - KCNA5

PR:000000812 - http://purl.obolibrary.org/obo/PR_000000812
Ontology Information
PRO ID PR:000000812 Show OBO stanza / PAF
PRO name voltage-gated potassium channel subunit KCNA5
Synonyms
PRO-short-label: KCNA5
EXACT: HPCN1; KV1-5; voltage-gated potassium channel HK2; voltage-gated potassium channel subunit Kv1.5
Definition A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone. [PMID:10575199, PMID:16772329, PMID:18344374]
PRO Category gene
Parent PR:000000709 shaker-related voltage-gated potassium channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 3 organism-sequence 6
modification 1 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036568
hKCNA5/iso:1/var:E375*
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:16772329
has_part NOT Pfam:PF00520 Ion transport protein PMID:16772329
PR:P22460-1
hKCNA5/iso:1
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:1986382
PR:Q61762-1
mKCNA5/iso:1
capable_of GO:0005249 voltage-gated potassium channel activity MGI:63618, PMID:8226976
located_in GO:0005887 integral component of plasma membrane MGI:63618, PMID:8226976
participates_in GO:0006813 potassium ion transport MGI:63618, PMID:8226976
PR:000002684
KCNA5/iso:2/UnMod
located_in GO:0005887 integral component of plasma membrane MGI:63618, PMID:8226976
PR:Q61762-3
mKCNA5/iso:3
capable_of GO:0019870 potassium channel inhibitor activity MGI:63618, PMID:8226976
participates_in GO:0043267 negative regulation of potassium ion transport MGI:63618, PMID:8226976
PR:Q61762-2
mKCNA5/iso:2
capable_of GO:0005249 voltage-gated potassium channel activity MGI:63618, PMID:8226976
has_part NOT Pfam:PF02214 BTB/POZ domain
located_in GO:0005887 integral component of plasma membrane MGI:63618, PMID:8226976
participates_in GO:0006813 potassium ion transport MGI:63618, PMID:8226976
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006813 potassium ion transport PR:Q61762-1 mKCNA5/iso:1

MGI:63618, PMID:8226976
PR:Q61762-2 mKCNA5/iso:2

MGI:63618, PMID:8226976
GO:0043267 negative regulation of potassium ion transport PR:Q61762-3 mKCNA5/iso:3

MGI:63618, PMID:8226976
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005887 integral component of plasma membrane PR:000002684 KCNA5/iso:2/UnMod

MGI:63618, PMID:8226976
PR:Q61762-1 mKCNA5/iso:1

MGI:63618, PMID:8226976
PR:Q61762-2 mKCNA5/iso:2

MGI:63618, PMID:8226976

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