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Protein Ontology Report - KCNH2

PR:000000791 - http://purl.obolibrary.org/obo/PR_000000791
Ontology Information
PRO ID PR:000000791 Show OBO stanza / PAF
PRO name voltage-gated potassium channel KCNH2
Synonyms
PRO-short-label: KCNH2
EXACT: ERG-1; Eag homolog; Eag-related protein 1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; voltage-gated potassium channel subunit Kv11.1
Gene-based: ERG; ERG1; HERG
RELATED: KHCN2
Definition A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000721 voltage-gated potassium channel Erg alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 4 organism-sequence 9
modification 6 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q12809
hKCNH2
participates_in GO:0008016 regulation of heart contraction PMID:7736582
participates_in GO:0006936 muscle contraction PMID:7736582
PR:000036583
hKCNH2/iso:A/Phos:1
capable_of GO:0005251 delayed rectifier potassium channel activity decreased relative to PR:000002666 KCNH2/iso:A/UnMod PMID:10837251
part_of GO:0008076 voltage-gated potassium channel complex PMID:10837251
PR:000045393
hKCNH2/iso:A/PhosRes-
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:10837251, PMID:9351446
PR:000045392
hKCNH2/iso:A/UnGlyco:1
Asn-598, PR:000026291 		located_in GO:0009986 cell surface PMID:12063277
PR:O35219-1
mKCNH2/iso:A
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9351446, PMID:9351462
located_in GO:0005886 plasma membrane MGI:3040012, PMID:14668215
located_in GO:0005635 nuclear envelope MGI:3040012, PMID:14668215
located_in GO:0005635 nuclear envelope PMID:14668215
located_in GO:0005737 cytoplasm MGI:3040012, PMID:14668215
located_in GO:0005737 cytoplasm PMID:14668215
part_of GO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:Q12809-2
hKCNH2/iso:B
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9351446
PR:Q12809-1
hKCNH2/iso:A
capable_of GO:0030552 cAMP binding PMID:10837251
PR:000036581
hKCNH2/iso:A/NGlyco:1
Asn-598, MOD:00160 		located_in GO:0009986 cell surface PMID:12063277
part_of GO:0008076 voltage-gated potassium channel complex PMID:12063277
PR:000036582
mKCNH2/iso:A/NGlyco:1
Asn-600, MOD:00160 		located_in GO:0005886 plasma membrane PMID:14668215
PR:O35219-2
mKCNH2/iso:1A'
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9351462
part_of GO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:Q12809-5
hKCNH2/iso:A-USO
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9765245
part_of GO:0008076 voltage-gated potassium channel complex PMID:9765245
PR:O35219-3
mKCNH2/iso:B
capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9351446, PMID:9351462
has_part NOT Pfam:PF00989 PAS fold PMID:9351446
part_of GO:0008076 voltage-gated potassium channel complex PMID:9351462
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0008016 regulation of heart contraction PR:Q12809 hKCNH2

PMID:7736582
GO:0006936 muscle contraction PR:Q12809 hKCNH2

PMID:7736582
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005635 nuclear envelope PR:O35219-1 mKCNH2/iso:A

MGI:3040012, PMID:14668215
PR:O35219-1 mKCNH2/iso:A

PMID:14668215
GO:0009986 cell surface PR:000036581 hKCNH2/iso:A/NGlyco:1
Asn-598, MOD:00160
PMID:12063277
PR:000045392 hKCNH2/iso:A/UnGlyco:1
Asn-598, PR:000026291
PMID:12063277
GO:0005737 cytoplasm PR:O35219-1 mKCNH2/iso:A

MGI:3040012, PMID:14668215
PR:O35219-1 mKCNH2/iso:A

PMID:14668215
GO:0005886 plasma membrane PR:000036582 mKCNH2/iso:A/NGlyco:1
Asn-600, MOD:00160
PMID:14668215
PR:O35219-1 mKCNH2/iso:A

MGI:3040012, PMID:14668215

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