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Protein Ontology Report - CNGA1

PR:000000686 - http://purl.obolibrary.org/obo/PR_000000686
Ontology Information
PRO ID PR:000000686 Show OBO stanza / PAF
PRO name cGMP-gated cation channel alpha-1
Synonyms
PRO-short-label: CNGA1
EXACT: CNG channel alpha-1; CNG-1; CNG1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha
Gene-based: CNCG; CNCG1
Definition A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. [PRO:CNA]
PRO Category gene
Parent PR:000000673 cyclic nucleotide-gated channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 4
modification 3 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036569
cow-CNGA1/iso:1/Phos:1
Tyr-498, MOD:00048 		capable_of GO:0030553 cGMP binding decreased relative to PR:000002593 obsolete cGMP-gated cation channel alpha-1 isoform 1 unmodified form PMID:10366613
PR:P29973-1
hCNGA1/iso:1
located_in GO:0005887 integral component of plasma membrane PMID:7479749
PR:P29974
mCNGA1
located_in GO:0001750 photoreceptor outer segment PMID:15634774
PR:000045381
cow-CNGA1/iso:1/UnPhos:1
Tyr-498, PR:000026291 		capable_of GO:0030553 cGMP binding PMID:10366613
PR:000000738
hCNGA1/var:S320F
Ser-320, CHEBI:29997 		associated_with_disease_progression DOID:10584 retinitis pigmentosa PMID:7479749
located_in NOT GO:0005887 integral component of plasma membrane PMID:7479749
PR:Q00194-1
cow-CNGA1/iso:1
part_of GO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12432397, PMID:12467591
Cellular Location GO Term Protein Forms & Complexes Evidence
NOT GO:0005887 integral component of plasma membrane PR:000000738 hCNGA1/var:S320F
Ser-320, CHEBI:29997
PMID:7479749
GO:0001750 photoreceptor outer segment PR:P29974 mCNGA1

PMID:15634774
GO:0005887 integral component of plasma membrane PR:P29973-1 hCNGA1/iso:1

PMID:7479749

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