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Protein Ontology Report - hTGFB1/var:R218H/Clv:1

PR:000000627 - http://purl.obolibrary.org/obo/PR_000000627
Ontology Information
PRO ID PR:000000627 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant R218H cleaved 1 (human)
Synonyms
PRO-short-label: hTGFB1/var:R218H/Clv:1
EXACT: TGF-beta 1 sequence variant 4 cleaved 1 (human)
PRO-proteoform-std: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979
Definition A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979. [PMID:11278244, PRO:CNA, PRO:DAN]
PRO Category organism-modification
Parent PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000627
hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979 		capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:12493741, PMID:12843182
capable_of GO:0042803 protein homodimerization activity PMID:11278244
capable_of GO:0005160 transforming growth factor beta receptor binding PMID:11278244
located_in GO:0005615 extracellular space PMID:11278244
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000627 hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979
PMID:11278244
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000000627 hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979
PMID:11278244

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