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Protein Ontology Report - hTGFB1/var:H222D

PR:000000402 - http://purl.obolibrary.org/obo/PR_000000402
Ontology Information
PRO ID PR:000000402 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant H222D (human)
Synonyms
PRO-short-label: hTGFB1/var:H222D
EXACT: TGF-beta 1 sequence variant 5 (human)
PRO-proteoform-std: UniProtKB:P01137, His-222, CHEBI:29958
Definition A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958. [PMID:12493741, PRO:CNA, PRO:DAN]
PRO Category organism-sequence
Parent PR:P01137 transforming growth factor beta-1 (human)
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000402
hTGFB1/var:H222D
His-222, CHEBI:29958 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
participates_in GO:0043066 negative regulation of apoptotic process PMID:12493741
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000000402 hTGFB1/var:H222D
His-222, CHEBI:29958
PMID:12493741
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000402 hTGFB1/var:H222D
His-222, CHEBI:29958
PMID:12493741

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