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Protein Ontology Report - SMAD7

PR:000000374 - http://purl.obolibrary.org/obo/PR_000000374
Ontology Information
PRO ID PR:000000374 Show OBO stanza / PAF
PRO name smad7
Synonyms
PRO-short-label: SMAD7
EXACT: MAD homolog 7; MAD homolog 8; SMAD 7; SMAD family member 7; mothers against DPP homolog 7; mothers against DPP homolog 8; mothers against decapentaplegic homolog 8
Gene-based: MADH7; MADH8
Definition An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling. [PMID:17438144]
PRO Category gene
Parent PR:000000099 inhibitory smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 2 organism-sequence 5
modification 6 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036565
hSMAD7/iso:1/Ac:1
Lys-64/Lys-70, MOD:00064 		capable_of GO:0140416 transcription regulator inhibitor activity PMID:12408818
located_in GO:0005634 nucleus PMID:11278814
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12408818
PR:O15105-1
hSMAD7/iso:1
capable_of GO:0140416 transcription regulator inhibitor activity PMID:9215638
capable_of GO:0005515 protein binding PMID:9256479
located_in GO:0005634 nucleus PMID:11278814
participates_in GO:0006950 response to stress PMID:9256479
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:10823886, PMID:9215638
PR:000036932
mSMAD7/iso:1/Phos:1
Ser-249, MOD:00046 		capable_of GO:0140416 transcription regulator inhibitor activity PMID:11278814
located_in GO:0005634 nucleus PMID:11278814
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278814
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006950 response to stress PR:O15105-1 hSMAD7/iso:1

PMID:9256479
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000036565 hSMAD7/iso:1/Ac:1
Lys-64/Lys-70, MOD:00064
PMID:12408818
PR:000036932 mSMAD7/iso:1/Phos:1
Ser-249, MOD:00046
PMID:11278814
PR:O15105-1 hSMAD7/iso:1

PMID:10823886, PMID:9215638
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036565 hSMAD7/iso:1/Ac:1
Lys-64/Lys-70, MOD:00064
PMID:11278814
PR:000036932 mSMAD7/iso:1/Phos:1
Ser-249, MOD:00046
PMID:11278814
PR:O15105-1 hSMAD7/iso:1

PMID:11278814

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