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Protein Ontology Report - SMURF1

PR:000000361 - http://purl.obolibrary.org/obo/PR_000000361
Ontology Information
PRO ID PR:000000361 Show OBO stanza / PAF
PRO name E3 ubiquitin-protein ligase SMURF1
Synonyms
PRO-short-label: SMURF1
EXACT: HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; smad ubiquitination regulatory factor 1
Gene-based: KIAA1625
Definition A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000127 smad ubiquitination regulatory factor
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 0 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q9HCE7
hSMURF1
participates_in GO:0030514 negative regulation of BMP signaling pathway PMID:10458166
PR:Q9CUN6
mSMURF1
participates_in GO:0030514 negative regulation of BMP signaling pathway PMID:14711801
PR:Q9CUN6-1
mSMURF1/iso:Short
located_in GO:0005622 intracellular anatomical structure PMID:14711801
PR:Q9HCE7-2
hSMURF1/iso:Short
capable_of GO:0004842 ubiquitin-protein transferase activity PMID:10458166
capable_of GO:0005515 protein binding PMID:11278251, PMID:16299379
located_in GO:0005622 intracellular anatomical structure PMID:10458166
participates_in GO:0030579 ubiquitin-dependent SMAD protein catabolic process PMID:12857866
participates_in GO:0006511 ubiquitin-dependent protein catabolic process PMID:10458166
participates_in GO:0006464 cellular protein modification process PMID:10458166
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030514 negative regulation of BMP signaling pathway PR:Q9CUN6 mSMURF1

PMID:14711801
PR:Q9HCE7 hSMURF1

PMID:10458166
GO:0006511 ubiquitin-dependent protein catabolic process PR:Q9HCE7-2 hSMURF1/iso:Short

PMID:10458166
GO:0030579 ubiquitin-dependent SMAD protein catabolic process PR:Q9HCE7-2 hSMURF1/iso:Short

PMID:12857866
GO:0006464 cellular protein modification process PR:Q9HCE7-2 hSMURF1/iso:Short

PMID:10458166
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005622 intracellular anatomical structure PR:Q9CUN6-1 mSMURF1/iso:Short

PMID:14711801
PR:Q9HCE7-2 hSMURF1/iso:Short

PMID:10458166

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