Entry Report [PIR] - PR:000000125

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000000125 Show OBO stanza / PAF

PRO name

zinc finger FYVE domain-containing protein 9

Synonyms

PRO-short-label:	ZFYVE9
EXACT:	Madh-interacting protein; mothers against decapentaplegic homolog-interacting protein; novel serine protease; receptor activation anchor; smad anchor for receptor activation
Gene-based:	MADHIP; SARA; SMADIP
RELATED:	NSP

Definition

A sara-type zinc finger FYVE domain-containing protein that is a translation product of the human ZFYVE9 gene or a 1:1 ortholog thereof. [PRO:CNA]

PRO Category

gene

Parent

PR:000000026 sara-type zinc finger FYVE domain-containing protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

ZFYVE9 forms found in complexes

ZFYVE9 Component	Complexes
PR:000000125 ZFYVE9	PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:O95405 hZFYVE9	PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:O95405-2 hZFYVE9/iso:2	located_in	GO:0005615 extracellular space	PMID:9582421
PR:O95405-3 hZFYVE9/iso:3	located_in	GO:0005615 extracellular space	PMID:9582421
PR:000000125 ZFYVE9	participates_in	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	PANTHER:PTHR22835:SF7
PR:O95405-1 hZFYVE9/iso:1	capable_of	GO:0005515 protein binding with PR:P08100 hRHO	PMID:17693260
	capable_of	GO:0005515 protein binding with PR:000025960 hSMAD2/iso:[Long/Short]/UnPhos:1	PMID:11877415, PMID:9865696
	located_in	GO:0005769 early endosome	PMID:11877415, PMID:12356868, PMID:12432064
	participates_in	GO:0007183 SMAD protein complex assembly	PMID:11877415, PMID:12356868
	participates_in	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:10615055
	participates_in	GO:0006897 endocytosis	PMID:12809483
	participates_in	GO:0060390 regulation of SMAD protein signal transduction	PMID:11877415, PMID:12356868

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0007183 SMAD protein complex assembly	PR:O95405-1 hZFYVE9/iso:1	PMID:11877415, PMID:12356868
GO:0006897 endocytosis	PR:O95405-1 hZFYVE9/iso:1	PMID:12809483
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	PR:000000125 ZFYVE9	PANTHER:PTHR22835:SF7
GO:0007179 transforming growth factor beta receptor signaling pathway	PR:O95405-1 hZFYVE9/iso:1	PMID:10615055
GO:0060390 regulation of SMAD protein signal transduction	PR:O95405-1 hZFYVE9/iso:1	PMID:11877415, PMID:12356868

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