PRO Term |
GO Annotation |
Evidence |
PR:000036294
hPITX2/iso:4
|
capable_of |
NOT
GO:0003677 DNA binding
|
PMID:11948188 |
capable_of |
GO:0005515 protein binding
with PR:Q99697-3 hPITX2/iso:Ptx2A
|
PMID:11948188 |
capable_of |
GO:0005515 protein binding
with PR:Q99697-2 hPITX2/iso:Ptx2C
|
PMID:11948188 |
participates_in |
GO:0043433 negative regulation of DNA-binding transcription factor activity
|
PMID:11948188 |
PR:P97474-1
mPITX2/iso:Ptx2B
|
part_of |
GO:0005667 transcription factor complex
|
PMID:12464179, PMID:15385555 |
participates_in |
GO:0007368 determination of left/right symmetry
|
PMID:12397115 |
participates_in |
GO:0016055 Wnt signaling pathway
|
PMID:12464179 |
PR:P97474-3
mPITX2/iso:Ptx2A
|
capable_of |
GO:0008134 transcription factor binding
|
PMID:15385555 |
capable_of |
GO:0005515 protein binding
with PR:Q9JM73 mSRF
|
MGI:3796777, PMID:18458156 |
capable_of |
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
|
MGI:3796777, PMID:18458156 |
capable_of |
GO:0003677 DNA binding
|
MGI:3796777, PMID:18458156 |
capable_of |
GO:0003712 transcription coregulator activity
|
MGI:3796777, PMID:18458156 |
located_in |
GO:0005634 nucleus
|
MGI:3796777, PMID:18458156 |
located_in |
GO:0005634 nucleus
|
PMID:11854422 |
participates_in |
NOT
GO:0007368 determination of left/right symmetry
|
PMID:10585561 |
participates_in |
GO:0007266 Rho protein signal transduction
|
PMID:11854422 |
participates_in |
GO:0043388 positive regulation of DNA binding
|
MGI:3796777, PMID:18458156 |
participates_in |
GO:0031532 actin cytoskeleton reorganization
|
PMID:11854422 |
PR:Q99697-1
hPITX2/iso:Ptx2B
|
capable_of |
GO:0005515 protein binding
with PR:Q99697-3 hPITX2/iso:Ptx2A
|
PMID:11948188 |
capable_of |
GO:0005515 protein binding
with PR:Q99697-2 hPITX2/iso:Ptx2C
|
PMID:11948188 |
participates_in |
GO:0007368 determination of left/right symmetry
|
PMID:9708732 |
participates_in |
GO:0009887 animal organ morphogenesis
|
PMID:9618168 |
PR:P97474-2
mPITX2/iso:Ptx2C
|
participates_in |
GO:0007368 determination of left/right symmetry
|
PMID:9708732 |
participates_in |
GO:0007179 transforming growth factor beta receptor signaling pathway
|
PMID:10585561 |
participates_in |
GO:0007520 myoblast fusion
|
MGI:3686567, PMID:16958127 |
participates_in |
GO:2000288 positive regulation of myoblast proliferation
|
MGI:3686567, PMID:16958127 |
participates_in |
GO:0009887 animal organ morphogenesis
|
PMID:10585561 |
PR:000000302
hPITX2/var:R137P
Arg-137, CHEBI:50342
|
associated_with_disease_progression |
DOID:14686 Axenfeld-Rieger syndrome
|
PMID:8944018 |
PR:000000301
hPITX2/var:R115H
Arg-115, CHEBI:29979
|
associated_with_disease_progression |
DOID:0050786 iridogoniodysgenesis syndrome
|
PMID:9618168 |
PR:000000300
hPITX2/var:T114P
Thr-114, CHEBI:50342
|
associated_with_disease_progression |
DOID:14686 Axenfeld-Rieger syndrome
|
PMID:8944018 |
PR:000000299
hPITX2/var:L100Q
Leu-100, CHEBI:30011
|
associated_with_disease_progression |
DOID:14686 Axenfeld-Rieger syndrome
|
PMID:8944018 |
PR:000000298
hPITX2/var:R89W
Arg-89, CHEBI:29954
|
associated_with_disease_progression |
DOID:0050786 iridogoniodysgenesis syndrome
|
PMID:9437321 |
PR:Q99697-3
hPITX2/iso:Ptx2A
|
capable_of |
GO:0008134 transcription factor binding
|
PMID:16449236 |
capable_of |
GO:0005515 protein binding
with PR:Q99697-2 hPITX2/iso:Ptx2C
|
PMID:11948188 |
located_in |
GO:0005634 nucleus
|
PMID:16449236 |
PR:000000297
PITX2/iso:4
|
has_part |
NOT
Pfam:PF00046 Homeodomain
|
|
PR:Q99697-2
hPITX2/iso:Ptx2C
|
capable_of |
GO:0005515 protein binding
with PR:Q99697-3 hPITX2/iso:Ptx2A
|
PMID:11948188 |
capable_of |
GO:0003677 DNA binding
|
PMID:11948188 |
capable_of |
GO:0005515 protein binding
with PR:Q99697-1 hPITX2/iso:Ptx2B
|
PMID:11948188 |
participates_in |
GO:0007507 heart development
|
PMID:11948188 |
|