back to PRO homepage

Protein Ontology Report - ACVR1

PR:000000067 - http://purl.obolibrary.org/obo/PR_000000067
Ontology Information
PRO ID PR:000000067 Show OBO stanza / PAF
PRO name activin receptor type-1
Synonyms
PRO-short-label: ACVR1
EXACT: ACTR-I; ALK-2; SKR1; TSK-7L; activin receptor type I; activin receptor-like kinase 2; serine/threonine-protein kinase receptor R1
Gene-based: ACVRLK2; Tgfb1
RELATED: TGF-B superfamily receptor type I; TSR-I
Definition A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000006 TGF-beta superfamily receptor type-1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 3
modification 3 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000200
hACVR1/var:R206H
Arg-206, CHEBI:29979 		associated_with_disease_progression DOID:13374 fibrodysplasia ossificans progressiva PMID:8397373
located_in GO:0005887 integral component of plasma membrane PMID:8397373
PR:000036435
hACVR1/iso:1/SigPep-/Phos:1
capable_of GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8389764
capable_of GO:0048185 activin binding PMID:8242742
located_in GO:0005887 integral component of plasma membrane PMID:8242742, PMID:8397373
part_of GO:0048179 activin receptor complex PMID:8242742
participates_in GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:8242742, PMID:8389764
PR:000036436
mACVR1/iso:1/SigPep-/Phos:1
participates_in GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:11376112
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PR:000036435 hACVR1/iso:1/SigPep-/Phos:1

PMID:8242742, PMID:8389764
PR:000036436 mACVR1/iso:1/SigPep-/Phos:1

PMID:11376112
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005887 integral component of plasma membrane PR:000000200 hACVR1/var:R206H
Arg-206, CHEBI:29979
PMID:8397373
PR:000036435 hACVR1/iso:1/SigPep-/Phos:1

PMID:8242742, PMID:8397373

top