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Protein Ontology Report - BMPR1B

PR:000000036 - http://purl.obolibrary.org/obo/PR_000000036
Ontology Information
PRO ID PR:000000036 Show OBO stanza / PAF
PRO name BMP receptor type-1B
Synonyms
PRO-short-label: BMPR1B
EXACT: ALK-6; BMP type-1B receptor; BMPR-1B; CDw293; SKR6; activin receptor-like kinase 6; serine/threonine-protein kinase receptor R6
Gene-based: Acvrlk6
Definition A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1. [PRO:CNA]
PRO Category gene
Parent PR:000000006 TGF-beta superfamily receptor type-1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 5
modification 2 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:O00238-1
hBMPR1B/iso:1
participates_in GO:0030509 BMP signaling pathway PMID:10051328
PR:000036426
hBMPR1B/iso:1/Phos:1
participates_in GO:0045597 positive regulation of cell differentiation PMID:14523231
participates_in GO:0030509 BMP signaling pathway PMID:10051328
PR:000036425
mBMPR1B/iso:1/Phos:1
located_in GO:0009986 cell surface PMID:10712517, PMID:14523231
part_of GO:0043235 receptor complex PMID:10712517
participates_in GO:0035108 limb morphogenesis PMID:14523231
participates_in GO:0001501 skeletal system development PMID:14523231
participates_in GO:0001502 cartilage condensation PMID:10631181, PMID:14523231
PR:000000147
hBMPR1B/var:R486W
Arg-486, CHEBI:29954 		associated_with_disease_progression DOID:0050581 brachydactyly PMID:14523231
capable_of GO:0004674 protein serine/threonine kinase activity PMID:14523231
located_in GO:0009986 cell surface PMID:14523231
PR:000000146
hBMPR1B/var:I200K
Ile-200, CHEBI:29967 		associated_with_disease_progression DOID:0050581 brachydactyly PMID:14523231
capable_of NOT GO:0004674 protein serine/threonine kinase activity PMID:14523231
located_in GO:0009986 cell surface PMID:14523231
PR:P36898-1
mBMPR1B/iso:1
located_in GO:0009986 cell surface PMID:10712517
participates_in GO:0001501 skeletal system development PMID:14523231
participates_in GO:0035108 limb morphogenesis PMID:14523231
participates_in GO:0001502 cartilage condensation PMID:14523231
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0035108 limb morphogenesis PR:000036425 mBMPR1B/iso:1/Phos:1

PMID:14523231
PR:P36898-1 mBMPR1B/iso:1

PMID:14523231
GO:0001502 cartilage condensation PR:000036425 mBMPR1B/iso:1/Phos:1

PMID:10631181, PMID:14523231
PR:P36898-1 mBMPR1B/iso:1

PMID:14523231
GO:0001501 skeletal system development PR:000036425 mBMPR1B/iso:1/Phos:1

PMID:14523231
PR:P36898-1 mBMPR1B/iso:1

PMID:14523231
GO:0045597 positive regulation of cell differentiation PR:000036426 hBMPR1B/iso:1/Phos:1

PMID:14523231
GO:0030509 BMP signaling pathway PR:000036426 hBMPR1B/iso:1/Phos:1

PMID:10051328
PR:O00238-1 hBMPR1B/iso:1

PMID:10051328
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:000000146 hBMPR1B/var:I200K
Ile-200, CHEBI:29967
PMID:14523231
PR:000000147 hBMPR1B/var:R486W
Arg-486, CHEBI:29954
PMID:14523231
PR:000036425 mBMPR1B/iso:1/Phos:1

PMID:10712517, PMID:14523231
PR:P36898-1 mBMPR1B/iso:1

PMID:10712517

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