back to PRO homepage

Protein Ontology Report - mitogen-activated protein kinase

PR:000000019 - http://purl.obolibrary.org/obo/PR_000000019
Ontology Information
PRO ID PR:000000019 Show OBO stanza / PAF
PRO name mitogen-activated protein kinase
Synonyms
EXACT: MAPK
RELATED: kinase-related transforming protein
Definition A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY. [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000019
mitogen-activated protein kinase
capable_of GO:0004672 protein kinase activity PIRSF:PIRSF501110
has_part Pfam:PF00069 Protein kinase domain PIRSF:PIRSF501110
participates_in GO:0006468 protein phosphorylation PIRSF:PIRSF501110
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000000019 mitogen-activated protein kinase

PIRSF:PIRSF501110

top