back to PRO homepage

Protein Ontology Report - IFNG

PR:000000017 - http://purl.obolibrary.org/obo/PR_000000017
Ontology Information
PRO ID PR:000000017 Show OBO stanza / PAF
PRO name interferon gamma
Synonyms
PRO-short-label: IFNG
EXACT: IFN-gamma; immune interferon
Definition A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions. [PRO:CNA]
PRO Category gene
Parent PR:000024990 type II interferon
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 2
modification 5 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036420
hIFNG/iso:1/ClvNGlyco:2
Asn-48/Asn-120, MOD:00160 		capable_of GO:0042803 protein homodimerization activity PMID:1902591
PR:000036418
mIFNG/iso:1/SigPep-
capable_of GO:0005125 cytokine activity PMID:11441112
participates_in GO:0050776 regulation of immune response PMID:11441112
PR:000036419
hIFNG/iso:1/SigPep-/NGlyco:1
Asn-48/Asn-120, MOD:00160 		capable_of GO:0005133 interferon-gamma receptor binding PMID:10986460
capable_of GO:0042803 protein homodimerization activity PMID:3109913
located_in GO:0005615 extracellular space PMID:6427223
PR:P01580-1
mIFNG/iso:1
participates_in GO:0032722 positive regulation of chemokine production PMID:12925700
participates_in GO:0042742 defense response to bacterium PMID:17661079
PR:000000017
IFNG
has_part Pfam:PF00714 Interferon gamma PIRSF:PIRSF001936
participates_in GO:0032722 positive regulation of chemokine production PIRSF:PIRSF001936
participates_in GO:0006955 immune response PIRSF:PIRSF001936
PR:000036407
mIFNG/iso:1/SigPep-/GlycoRes+
MOD:00693 		capable_of GO:0005125 cytokine activity PMID:11027433, PMID:12925700, PMID:15240719
located_in GO:0005615 extracellular space PMID:11057672, PMID:11728336, PMID:15240714
participates_in GO:0050776 regulation of immune response PMID:12882831
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0050776 regulation of immune response PR:000036407 mIFNG/iso:1/SigPep-/GlycoRes+
MOD:00693
PMID:12882831
PR:000036418 mIFNG/iso:1/SigPep-

PMID:11441112
GO:0006955 immune response PR:000000017 IFNG

PIRSF:PIRSF001936
GO:0042742 defense response to bacterium PR:P01580-1 mIFNG/iso:1

PMID:17661079
GO:0032722 positive regulation of chemokine production PR:000000017 IFNG

PIRSF:PIRSF001936
PR:P01580-1 mIFNG/iso:1

PMID:12925700
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036407 mIFNG/iso:1/SigPep-/GlycoRes+
MOD:00693
PMID:11057672, PMID:11728336, PMID:15240714
PR:000036419 hIFNG/iso:1/SigPep-/NGlyco:1
Asn-48/Asn-120, MOD:00160
PMID:6427223

top