PMID: 22357623 RLIMS-P 40 Check other iTextMine results Issue Report
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Legend: SUBSTRATE KINASE INTERACTANT SITE GENE MIRNA ANOMALY EXPRESSION DISEASE OUTCOME/RESPONSE SR_DRUG DRUG CELL TRIGGER Normalized
Tool: RLIMS-P
| PTM enzyme | Substrate | Site | Sentence |
|---|---|---|---|
| Chk1 (O14757) | Ser-280 | 4.3 (introduction) 6.1, 7.1, 7.3, 8.1, 8.4, 8.6, 11.1, 13.9, 18.3, 23.5, 25.6, 26.1, 27.1 (results) 29.1, 29.4 (discussion) | |
| P90 RSK (Q15418) | Chk1 (O14757) | Ser-280 | 17.1, 20.1 (results) |
| p90 RSK (Q15418) | Chk1–Ser-280 | Ser-280 | 15.1 (results) 35.1 (other) |
| Bad | Ser-112, Ser-136 | 18.2 (results) | |
| p90 RSK (Q15418) | ERK1/2 | Tyr-204, Thr-202 | 13.2 (results) |
| Bad | Ser-112 | 13.6 (results) | |
| Chk1–Ser-280 | Ser-280 | 4.5, 4.6, 4.7 (introduction) 9.4, 13.1, 13.7, 13.8, 19.6, 22.1, 23.2, 23.3, 24.3, 24.4, 25.2, 25.8 (results) 30.4, 31.1, 31.2, 31.7, 33.1 (discussion) | |
| Akt/PKB | Ser-473, Thr-308 | 13.2, 13.7 (results) | |
| Chk1xSer-280 | 13.4 (results) | ||
| p90 RSK (Q15418) | Bad | Ser-112 | 13.2, 13.5 (results) |
| p90 RSK (Q15418) | Thr-573 | 2.5 (introduction) 13.2 (results) | |
| p90 RSK (Q15418) | Akt/PKB | Ser-473, Thr-308 | 13.2 (results) |
| Bad | Ser-136 | 13.7 (results) | |
| Chk1 (O14757) | Ser-296, Ser-345 | 4.7 (introduction) 23.4 (results) | |
| Akt/PKB | Thr-308, Thr-473 | 2.8 (introduction) | |
| Chk1 (O14757) | 3.6 (introduction) 8.2, 8.3, 14.1 (results) 45.1 (methods) | ||
| ATR (Q13535) | Chk1 (O14757) | Ser-345, Ser-317 | 3.5 (introduction) |
| Chk1 (O14757) | Chk1 (O14757) | Ser-296 | 3.5 (introduction) |
| Chk1 (p-Chk1) (O14757) | 8.3 (results) | ||
| MAPK cascade–p90 RSK pathway controls Chk1 | Ser-280 | 12.1 (results) | |
| Chk1–Ser-280 | Chk1 (O14757) | Ser-280 | 14.2 (results) |
| p90 RSK1 | Chk1 (O14757) | Ser-280 | 19.3, 19.4 (results) |
| p90 RSK1, Akt1 | Chk1 (O14757) | 19.2 (results) | |
| p90 RSK (Q15418) | Chk1 (O14757) | 19.5 (results) | |
| ATR (Q13535) | ATR (Q13535) | 32.5 (discussion) | |
| ATR (Q13535) | Chk1 (O14757) | Ser-345 | 32.5 (discussion) |
| p90 RSK (Q15418) | Chk1 (O14757) | Ser-280 | 21.1 (results) 30.3, 32.2 (discussion) |
| MAPK cascade–p90 RSK controls Chk1 | Ser-280 | 24.6 (results) | |
| WT protein | Ser-280 | 22.2, 22.4 (results) | |
| Chk1–Ser-280 | p90 RSK (Q15418) | 30.7 (discussion) | |
| Akt/PKB | Chk1 (O14757) | Ser-280 | 29.1, 29.3, 30.2 (discussion) |
| Akt/PKB | Chk1–Ser-280 | Ser-280 | 30.8 (discussion) |
| p90 RSK1 | Chk1 KD | 20.11 (results) | |
| Akt/PKB | 26.11 (results) 29.2 (discussion) | ||
| MK2 | 26.11 (results) | ||
| Chk1 (O14757) | Ser-296, Ser-345, Ser-280 | 26.12 (results) | |
| Chk1 (O14757) | Ser-345, Ser-296 | 23.3, 25.1, 25.7 (results) | |
| Chk1 (O14757) | Ser-345, Ser-280, Ser-296 | 23.5 (results) | |
| Chk1 (O14757) | Ser-280, Ser-345 | 23.6 (results) | |
| high-level Chk1 | Ser-280 | 23.4 (results) |