PMID: 27009840 RLIMS-P 1 Check other iTextMine results Issue Report
Title
| 1. | TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer. |
Abstract
| 2. | O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. |
| 3. | Although previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNActransferase are linked to the incidence of metastasis in triple negative breast cancer (TNBC) patients, the molecular basis behind this is not fully understood. |
| 4. | In this study, we have determined that the TAK1 binding protein 3 (TAB3) was O-GlcNAcylated at Ser408 by OGT in the TNBC, which was required for its Thr404 phosphorylation, TAK1 activation and downstream nuclear factor kappa B (NF-κB) activation in TNBC. |
| 5. | O-GlcNAcylation of TAB3 was induced by p38 MAPK and it in turn enhances the TAK1 mediated p38MAPK activation, which forms the positive feedback loop in TAB3mediated NF-κB activation. |
| 6. | In TNBC, TAB3O-GlcNAcylationmediated cell migration and invasion by activating its downstream NF-κB. |
| 7. | The expression of TAB3 O-GlcNAcylation increased in TNBC patients, and it was significantly correlated with poor prognoses of the patients. |
| 8. | Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in TNBC metastasis. |
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Legend: SUBSTRATE KINASE INTERACTANT SITE GENE MIRNA ANOMALY EXPRESSION DISEASE OUTCOME/RESPONSE SR_DRUG DRUG CELL TRIGGER Normalized
Tool: RLIMS-P
| PTM enzyme | Substrate | Site | Sentence |
|---|---|---|---|
| TAK1 binding protein 3 (TAB3) (Q8N5C8) | Thr-404 | 4 |