PMID: 18056989    RLIMS-P  3    Check other iTextMine results Issue Report


Title
1.The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Abstract
5.Pim-1L was co-localized with BCRP on the plasma membrane and induced phosphorylation of BCRP at threonine 362.
6.Knocking-down Pim-1L expression in the drug-resistant prostate cancer cells abolished multimer formation of endogenous BCRP and resensitized the resistant cells to chemotherapeutic drugs suggesting that BCRP phosphorylation induced by Pim-1L was essential for its functionality.
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Legend:   SUBSTRATE  KINASE  INTERACTANT  SITE  GENE  MIRNA  ANOMALY  EXPRESSION  DISEASE  OUTCOME/RESPONSE  SR_DRUG  DRUG  CELL  TRIGGER  Normalized

Tool: RLIMS-P

PTM enzymeSubstrateSiteSentence
BCRP (Q9UNQ0)6
BCRP (Q9UNQ0)Thr-3625
44-kDa Pim-1 kinaseBCRP/ABCG2 (Q9UNQ0)1