PMID: 22371556    RLIMS-P  2 eFIP  0 miRTex  0 eGARD  0  Issue Report


Title
1.aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.
Abstract
5.Upon recruitment to primordial junctions, aPKC phosphorylates JAM-A at S285 to promote the maturation of immature cell-cell contacts.
6.In fully polarized cells, S285-phosphorylated JAM-A is localized exclusively at the TJs, and S285 phosphorylation of JAM-A is required for the development of a functional epithelial barrier.
9.Our data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.
Loading...

Loading data

Legend:   SUBSTRATE  KINASE  INTERACTANT  SITE  GENE  MIRNA  ANOMALY  EXPRESSION  DISEASE  OUTCOME/RESPONSE  SR_DRUG  DRUG  CELL  TRIGGER  Normalized

Tool: RLIMS-P

PTM enzymeSubstrateSiteSentence
JAM-A (Q9Y624)Ser-2856
aPKCJAM-A (Q9Y624)Ser-2851, 5, 9