Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9Y4P1 / ATG4B_HUMAN
Protein Name Cysteine protease ATG4B
Gene Name Name: ATG4B
Organism Homo sapiens (Human)

DAG View
PRO Name cysteine protease ATG4B (human)
Definition A cysteine protease ATG4B that is encoded in the genome of human.
Short Label hATG4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9Y4P1 (ATG4B) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
Y8 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33607258, 29165041, 30443548
K39 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S121 Phosphorylation RLIMS-P 30443548
Y122 Phosphorylation PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S262 Phosphorylation RLIMS-P 30443548
S316 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28821708
K337 Ubiquitination PhosphoSitePlus
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 21406692, 17081983, ...31771238, 26378241, 24275569, 29232556, 19690332, 20068231
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26378241, 31771238, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S383 Phosphorylation HPRD 17322306, 19651622, 19664994, ...20068231
S392 Phosphorylation HPRD 19651622, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y4P1 (ATG4B) S316 Q9H492 (MAP1LC3A) decreased_association eFIP 28821708

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 I34 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S44 Y44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y122 C122 Biomuta DOID:9256 / colorectal cancer [ tcga ]