Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2R4 / DDX52_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX52
Gene Name Name: DDX52
Synonyms:ROK1;ORFNames:HUSSY-19;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2R4
DAG View
PRO Name probable ATP-dependent RNA helicase DDX52 (human)
Definition A probable ATP-dependent RNA helicase DDX52 that is encoded in the genome of human.
Short Label hDDX52
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2R4 (DDX52) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Acetylation PhosphoSitePlus   UniProt 19608861
S22 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
R27 Methylation PhosphoSitePlus
Y35 Phosphorylation phospho.ELM 18669648
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S40 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T105 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 G27 Biomuta DOID:1612 / breast cancer [ cosmic ]
K52 N52 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S110 A110 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K171 T171 Biomuta DOID:3070 / malignant glioma [ tcga ]
K409 R409 Biomuta DOID:1324 / lung cancer [ cosmic ]
K409 N409 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K521 N521 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K521 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]