Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULR0 / ISY1_HUMAN
Protein Name Pre-mRNA-splicing factor ISY1 homolog
Gene Name Name: ISY1
Synonyms:KIAA1160;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULR0
DAG View
PRO Name pre-mRNA-splicing factor ISY1 homolog (human)
Definition A pre-mRNA-splicing factor ISY1 that is encoded in the genome of human.
Short Label hISY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULR0 (ISY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K127 Acetylation PhosphoSitePlus   UniProt 19608861
K127 Ubiquitination PhosphoSitePlus
S222 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S227 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S247 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K260 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S222 Phosphorylation HPRD 17525332
S227 Phosphorylation HPRD 17525332
S247 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K127 R127 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S222 * Biomuta DOID:3571 / liver cancer [ icgc ]
S227 I227 Biomuta DOID:1324 / lung cancer [ cosmic ]
S269 R269 Biomuta DOID:3571 / liver cancer [ icgc ]